Tiflorex

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Tiflorex
Tiflorex.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C12H16F3NS
Molar mass 263.10 g/mol
3D model (Jmol)
Chirality Racemic mixture
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Tiflorex, formerly known as flutiorex, is a stimulant amphetamine. Its most pronounced effect is in suppression of appetite; it has little effect on pulse rate, sleep, or mood.[1] It was found to be twice as potent an anorectic as fenfluramine.[2]

SL 72.340-d was cited to be 4x the anorectant potency of fenfluramine (ED50=1.4mg/kg vs 5.6mg/kg).[3]

References[edit]

  1. ^ T. Silverstone, Jill Fincham & Jill Plumley. An evaluation of the anorectic activity in man of a sustained release formulation of tiflorex. British Journal of Clinical Pharmacology, 1979, 7, 353–356.
  2. ^ J.F. Giudicelli, Christine Richer & A. Berdeaux (1976). "Preliminary assessment of flutiorex, a new anorectic drug, in man.". British Journal of Clinical Pharmacology. 3 (1): 113–121. doi:10.1111/j.1365-2125.1976.tb00578.x. PMC 1428817Freely accessible. PMID 788737. 
  3. ^ https://books.google.co.uk/books?id=z_8kBQAAQBAJ&pg=PA356&lpg=PA356&dq=SL+72.340-d&source=bl&ots=Oe8zjyf7jX&sig=O5StbScjQ3jWdZ7dafliN7H3GkM&hl=en&sa=X&ved=0ahUKEwiw35Ho5eDMAhWNF8AKHW7CC8IQ6AEIHDAA#v=onepage&q=SL%2072.340-d&f=true