|Systematic (IUPAC) name|
|Legal status||Prescription Only (S4) (AU) Schedule III (US)|
|Routes||IV, IM, SC, Other|
|Mol. mass||223.34 g/mol|
|(what is this?)|
Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically and pharmacologically to other anesthetics in this family such as ketamine and phencyclidine. Tiletamine hydrochloride exists as odourless white crystals. It is used in veterinary medicine in the compound product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs. It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as polar bears and wood bison. Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.
- Klockgether, Thomas; Turski, Lechoslaw, Schwarz, Michael, Sontag, Karl-Heinz, Lehmann, John (1 October 1988). "Paradoxical convulsant action of a novel non-competitiveN-methyl-d-aspartate (NMDA) antagonist, tiletamine". Brain Research 461 (2): 343–348. doi:10.1016/0006-8993(88)90265-X.
- "Telazol". Retrieved 5 January 2012.
- Cattet, MR; Caulkett, NA, Lunn, NJ (July 2003). "Anesthesia of polar bears using xylazine-zolazepam-tiletamine or zolazepam-tiletamine.". Journal of wildlife diseases 39 (3): 655–64. PMID 14567228.
- Caulkett, NA; Cattet, MR, Cantwell, S, Cool, N, Olsen, W (January 2000). "Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations.". The Canadian veterinary journal. La revue veterinaire canadienne 41 (1): 49–53. PMC 1476335. PMID 10642872.
- Quail, MT; Weimersheimer, P, Woolf, AD, Magnani, B (2001). "Abuse of telazol: an animal tranquilizer.". Journal of toxicology. Clinical toxicology 39 (4): 399–402. PMID 11527235.
- "Lists of: Scheduling Actions, Controlled Substances, Regulated Chemicals". Drug Enforcement Administration. Retrieved 5 January 2012.
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