It is used in veterinary medicine in the compound product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs. It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as polar bears and wood bison. Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.
Abuse of Telazol has been documented. Animal studies have also shown that tiletamine produces rewarding and reinforcing effects. Tiletamine products are classified as Schedule IIIcontrolled substances in the United States.
^Quail, MT; Weimersheimer, P; Woolf, AD; Magnani, B (2001). "Abuse of telazol: an animal tranquilizer.". Journal of Toxicology: Clinical Toxicology. 39 (4): 399–402. doi:10.1081/clt-100105161. PMID11527235.
^de la Peña JB, Lee HC, de la Peña IC, Woo TS, Yoon SY, Lee HL, Han JS, Lee JI, Cho YJ, Shin CY, Cheong JH (2012). "Rewarding and reinforcing effects of the NMDA receptor antagonist-benzodiazepine combination, Zoletil®: difference between acute and repeated exposure". Behavioural Brain Research. 233 (2): 434–42. doi:10.1016/j.bbr.2012.05.038. PMID22659394.