McKyer is a three-time Super Bowl champion, two victories with the 49ers in 1988 and 1989 and one with the Denver Broncos in 1997. His best year as a pro came during his rookie season with San Francisco, intercepting 6 passes for 33 yards and 1 touchdown. He was an All Pro Corner for 2 NFL seasons and was named to the "All Madden Team". During the Carolina Panthers inaugural season, he intercepted a pass and scored on a ninety-six yard interception run for a touchdown to defeat the Super Bowl champion San Francisco 49ers. McKyer became a journeyman throughout the 1990s, bouncing from team to team until he ended his NFL career after the 1997 season. Though he is most likely remembered for giving up the game winning touchdown to Tony Martin in the 1994 AFC Championship Game while with the Pittsburgh Steelers. The touchdown allowed the heavy underdog San Diego Chargers reach Super Bowl XXIX in one of the biggest upsets in AFC Championship history.