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Clinical data
Trade names Fasigyn, Simplotan, Tindamax
AHFS/Drugs.com Monograph
MedlinePlus a604036
  • AU: B3
  • US: C (Risk not ruled out)
Routes of
ATC code J01XD02 (WHO) P01AB02 (WHO) QP51AA02 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Protein binding 12%
Metabolism Hepatic (CYP3A4)
Biological half-life 12–14 hours
Excretion Urine (20–25%), faeces (12%)
CAS Number 19387-91-8 YesY
PubChem (CID) 5479
DrugBank DB00911 YesY
ChemSpider 5279 YesY
UNII 033KF7V46H YesY
KEGG D01426 YesY
NIAID ChemDB 007940
ECHA InfoCard 100.039.089
Chemical and physical data
Formula C8H13N3O4S
Molar mass 247.273 g/mol
3D model (Jmol) Interactive image

Tinidazole is an anti-parasitic drug used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of amoebic and parasitic infections. It was developed in 1972. A derivative of 2-methylimidazole, it is a prominent member of the nitroimidazole antibiotics.[1]

Tinidazole is marketed by Mission Pharmacal under the brand name Tindamax, by Pfizer under the names Fasigyn and Simplotan, and in some Asian countries as Sporinex.


It is chemically similar to metronidazole—a drug with some unpleasant side effects that is used in the United States as first-line therapy for amoebae. Tinidazole has similar side effects but has a shorter treatment course.


A large body of clinical data exists to support use of tinidazole for infections from amoebae, giardia, and trichomonas, just like metronidazole. Tinidazole may be a therapeutic alternative in the setting of metronidazole tolerance. Tinidazole may also be used to treat a variety of other bacterial infections (e.g., as part of combination therapy for Helicobacter pylori eradication protocols).[2]

Side effects[edit]

The most common side effects reported with tinidazole are upset stomach, bitter taste and itchiness. Other side effects include headache, physical fatigue, and dizziness. Anecdotally, people who have taken both metronidazole and tinidazole report toxicity is much the same except the side effects don't last as long with the latter.

Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath.


Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.


  1. ^ Ebel, K., Koehler, H., Gamer, A. O., & Jäckh, R. “Imidazole and Derivatives.” In Ullmann’s Encyclopedia of Industrial Chemistry; 2002 Wiley-VCH, doi:10.1002/14356007.a13_661
  2. ^ Edwards, David I. "Nitroimidazole drugs - action and resistance mechanisms. I. Mechanism of action" Journal of Antimicrobial Chemotherapy 1993, volume 31, pp. 9-20. doi:10.1093/jac/31.1.9.

External links[edit]