Tioconazole

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Tioconazole
Tioconazole.svg
Clinical data
Trade names Vagistat-1
AHFS/Drugs.com Monograph
Routes of
administration
Topical
ATC code
Legal status
Legal status
Identifiers
Synonyms Thioconazole
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.059.958
Chemical and physical data
Formula C16H13Cl3N2OS
Molar mass 387.711 g/mol
Chirality Racemic mixture
 NYesY (what is this?)  (verify)

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast. It is marketed under the brand names Trosyd and Gyno-Trosyd (Pfizer). Tioconazole ointments serve to treat women's vaginal yeast infections.[1] They are available in one day doses, as opposed to the 7-day treatments more common in use in the past.

Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus".

Side effects[edit]

Side effects (for the women's formulas) may include temporary burning/irritation of the vaginal area, moderate drowsiness, headache similar to a sinus headache, hives, and upper respiratory infection.[citation needed] These side effects may be only temporary, and do not normally interfere with the patient's comfort enough to outweigh the end result.

Synthesis[edit]

Antimycotic imidazole derivative.

Tiaconazole synthesis:[2]

A displacement reaction between 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and 2-chloro-3-(chloromethyl)thiophene is performed.

References[edit]

  1. ^ Tioconazole, Mayo Clinic
  2. ^ G. E. Gymer, BE 841309 ; idem, U.S. Patent 4,062,966 (1976, 1977 both to Pfizer).