Capobianco was born in La Plata, Argentina. His parents had fled from Fascist Italy in 1928 and settled in La Plata, near Buenos Aires. His parents were both musical; his father played trumpet in the local symphonic band. He grew up speaking Italian (a later advantage in the opera world) and attended a bilingual Spanish-Italian school until 4th grade. He continued his musical education at Hermanos Maristas de la Enseñanza and St. Joseph's College. He then qualified for the chorus and opera school of the Teatro Argentino de La Plata where he graduated from being a super to singing baritone roles and also learned stage managing. 
He made his official debut with Aida at the Teatro Argentino de La Plata in 1953, then worked at the Teatro Colón in Buenos Aires. His American debut came in 1962 with a production of Tosca at the Philadelphia Grand Opera Company with Birgit Nilsson in the title role.
Capobianco was artistic director of the Cincinnati Opera Festival (1961 to 1965) and the Cincinnati Opera (1962 to 1965) before moving to the New York City Opera in 1965 with Les contes d'Hoffmann which included Beverly Sills and Norman Treigle in the cast. Then followed posts at the San Diego Opera and the Pittsburgh Opera.
A man who has been described as difficult to work with and who "admits his intense management and directing style was at times hard on his singers and staff: 'I am obsessed with something that does not exist: perfection.'", Capobianco seemed to relish the control which the post of general director gave to him: "The impetus of general director was the assurance to me that I could do whatever I wanted. There will be nobody except the board to stop me. I don't believe in democracy in the arts. You don't use four persons to do the same painting."
In 2017, his autobiography, Tito's Way: The Art of Producing Opera, was published.
New York City Opera, 1966 to 1976
Capobianco was to become one of the City Opera's important directors, mounting ground-breaking productions including Alberto Ginastera's Don Rodrigo (with Plácido Domingo), Giulio Cesare (which brought Sills to preëminence in 1966), Le Coq d'Or, Manon, Mefistofele (with Treigle in his greatest role), Lucia di Lammermoor, Les contes d'Hoffmann, I puritani, Il turco in Italia and the world premiere of Menotti's La Loca.
In addition there was the now-famous "The Three Queens" operas of Donizetti, Roberto Devereux (1970), Maria Stuarda (1972), and Anna Bolena, all of which starred Sills. He established a solid working relationship with Sills, and the feeling was mutual. "I can ask her to try anything onstage," said Capobianco, who directed most of her successes at City Opera and whom Sills regarded as "her" director." Capobianco commented on some of the features which allowed the trio of operas to be presented: "It was a golden era ... We had singers who could act. It was total theatre; drama. It was just a fantastic moment."
In a statement after his death, Opera News described him as a "groundbreaking director during New York City Opera's heyday" and as "one of the most influential directors in opera during the 1960s and '70s".
San Diego Opera, 1976 to 1983
He was General Director of the San Diego Opera from 1976 to 1983. During his tenure he "expanded the season to six productions, featuring renowned superstars such as Joan Sutherland, Luciano Pavarotti and Beverly Sills." Because of his friendship with Sills, the San Diego Opera presented her final performance in 1980, a production of Die Fledermaus, in which Sutherland and Sills sang the roles of Rosalinde and Adele.
One of the features of his tenure at the company was the introduction of a Verdi Festival, with two operas presented each summer, one generally a late composition, the other an early work from the composer's "galley years". Beginning in 1976 with Otello as part of the regular season, the festival continued in the summers of 1978 with Verdi's Requiem and Aida; in 1979 with I Lombardi; in 1980 with Il trovatore and Giovanna d'Arco; in 1981 with Un giorno di regno plus the Requiem and 1982 saw stagings of Il corsaro and Un ballo in maschera. Capobianco left the company in 1983, but his successor was able to present I masnadieri (with Sutherland) along with Simon Boccanegra while the festival concept ended in March 1985 with Oberto (with Ferruccio Furlanetto and Susanne Marsee).
Pittsburgh Opera, 1983 to 2000
His 17-year tenure as general director of the Pittsburgh Opera was summed up as "armed with a towering personality, glittering charisma and determined artistic vision, he's ruled the Pittsburgh Opera – sometimes, say his critics, with an iron fist." A Twitter statement from the opera company at the time of this death said "Tito Capobianco was a legendary figure. With visionary leadership spanning over 17 years, he helped build Pittsburgh Opera into what it is today."[This quote needs a citation]
- Donizetti: Roberto Devereux (Sills, Marsee, J. Alexander, Fredricks; Rudel, 1975) [live] VAI
- Verdi: La traviata (Sills, H. Price, Fredricks; Rudel, 1976) [live] VAI
- Massenet: Manon (Sills, H. Price, Fredricks, Ramey; Rudel, 1977) [live] Paramount
- Verdi: Simon Boccanegra (Tomowa-Sintow, Milnes, Plishka; Levine, 1984) [live] Deutsche Grammophon
- Former Pittsburgh Opera Director Passes Away At Age 87
- Capobianco, Tito (2017). Tito's Way: The Art of Producing Opera. Branden Books. ISBN 9-780-8283-2651-3.
- Andrew Druckenbrod, "Final curtain: Tito Capobianco's tempestuous tenure at Pittsburgh Opera marked by financial and artistic gains", Pittsburgh Post-Gazette, 2 April 2000. Retrieved 11 September 2010
- Anthony J. Rudel, "Three Queens, One Soprano", essay in booklet accompanying the Three Queens ABC "Audio Treasury" recordings
- Capobianco in Time magazine, 22 November 1971, quoted on beverlysillsonline.com Retrieved 11 September 2010
- "Tito Capobianco, 87, Groundbreaking Director During New York City Opera's Heyday, has Died". Opera News. September 9, 2018. Retrieved 10 September 2018.
- "Company History" Archived 2014-07-02 at the Wayback Machine. on sdopera.com. Retrieved 2 June 2014
- "Beverly Sills". North Ohio Opera League. Retrieved 10 September 2018.
- San Diego Opera's "Performance History" page on sdopera.com Archived 2015-09-25 at the Wayback Machine. Retrieved 11 September 2011