Radloff has a distinctive manner of speech and quirky mannerisms. He is a self-proclaimed "Genuine Nerd," and is proud of it. He publicly came out as gay after the release of the American Splendor film in 2003.
Radloff met Pekar in 1980 when Radloff was hired at the VA Hospital, and soon became a recurring character in American Splendor. Radloff starred in such stories as "Lentils and Lent" (illustrated by Sean Carroll), "Double Feature Part 1: Footloose, Starring Toby Radloff" and "Double Feature Part 2: Revenge of the Nerds", (both illustrated by Bill Knapp), "Toby Saves the Day," (illustrated by Ed Wesolowski), and "Hollywood Reporter" and "Reduction" (both illustrated by Josh Neufeld).
Radloff is currently hosting "Cheapskate Theater", produced by filmmaker Wayne Alan Harold, the creator of Radloff's original MTV segments. The first installment's movie is the science-fiction horror classic Attack of the Giant Leeches.
- Dennis Hensley (September 3, 2003). "Revenge of the nerd". The Advocate. pp. 53–54.
- "Harvey Pekar's Artists," Josh Neufeld Comix & Stories. Archived 2009-03-12 at the Wayback Machine Accessed Jan. 28, 2009.
- Mitchell, Elvis (August 15, 2003). "American Splendor (2003) FILM REVIEW; A Comics Guy, Outside the Box". The New York Times.
- Panasci, Thomas; Kaplan, Jason (2006-08-03). "The Next Wack Packer". HowardStern.com. Retrieved 2010-02-06.
- Mercer, Mark (2006-08-03). "Thursday, August 3, 2006". Marksfriggin. Retrieved 2010-02-06.