Hollandsworth made his major league debut on April 25, 1995, for the Dodgers. He was named the 1996National LeagueRookie of the Year when he led all NL rookies that season in hits, doubles, home runs, runs batted in, and stolen bases in 149 games. His award was the fifth consecutive Rookie of the Year award for the Dodgers, an MLB record. Hollandsworth was a member of the 2003 World Series Champion Florida Marlins. The Braves acquired him on August 29, 2005, from the Cubs, for minor league pitchers Todd Blackford and Angelo Burrows.
In a 12-year Major League career, Hollandsworth compiled a .273 batting average with 98 home runs and 401 RBI.
Todd is married to Marci, sister of major league pitcher Matt Herges. The two were introduced to one another through Herges while both were Dodgers in 2000.
During the 2008 baseball season, Todd was a regular contributor to Comcast Sports Net Chicago commenting on the Chicago Cubs baseball season. In 2009, he became the pre- and post-game analyst for Comcast Sports Net Chicago's Cubs telecasts.