Togavirus 5' plus strand cis-regulatory element

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Togavirus 5' plus strand cis-regulatory element
Predicted secondary structure and sequence conservation of Toga_5_CRE
Symbol Toga_5_CRE
Rfam RF00470
Other data
RNA type Cis-reg
Domain(s) Viruses
SO 0000233

The Togavirus 5' plus strand cis-regulatory element is an RNA element which is thought to be essential for both plus and minus strand RNA synthesis.[1]

Genus Alphavirus belongs to the family Togaviridae. Alpha viruses contain secondary structural motifs in the 5' UTR that allow them to avoid detection by IFIT1.[2]

See also


  1. ^ Frolov, I; Hardy R; Rice CM (2001). "Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis". RNA. 7 (11): 1638–1651. doi:10.1017/S135583820101010X. PMC 1370205Freely accessible. PMID 11720292. 
  2. ^ Hyde, Jennifer L.; Gardner, Christina L.; Kimura, Taishi; White, James P.; Liu, Gai; Trobaugh, Derek W.; Huang, Cheng; Tonelli, Marco; Paessler, Slobodan (2014-02-14). "A viral RNA structural element alters host recognition of nonself RNA". Science. 343 (6172): 783–787. doi:10.1126/science.1248465. ISSN 1095-9203. PMC 4209899Freely accessible. PMID 24482115. 

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