|Preferred IUPAC name
o-Tolidine; Orthotolidine; Diaminoditolyl; Diaminotolyl; Bianisidine; Tolidine blue; 3,3'-Dimethylbenzidine; 4,4'-Bi-o-toluidine
3D model (Jmol)
|Molar mass||212.30 g·mol−1|
|Appearance||White to reddish crystals or powder|
|Melting point||129 °C (264 °F; 402 K)|
|Boiling point||300.5 °C (572.9 °F; 573.6 K)|
|Main hazards||potential carcinogen|
|R-phrases||R45 R22 R51/53|
|S-phrases||S53 S45 S61|
|Flash point||244 °C (471 °F; 517 K)|
|US health exposure limits (NIOSH):|
|Handle with care|
|Ca C 0.02 mg/m3 [60-minute] [skin]|
IDLH (Immediate danger)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
2-Tolidine (orthotolidine, o-tolidine) is an organic compound with the chemical formula (C6H4(CH3)NH2)2. Several isomers are known; the 3-tolidine derivative is also important commercially. It is a colorless compound although commercial samples are often colored. It is slightly soluble in water. It forms salts with acids, such as the hydrochloride, which is commercially available.
- (CH3C6H4)2N2H2 → (C6H3(CH3)NH2)2
It has also for the production of certain elastomers. 2-Tolidine is an intermediate for the production of soluble azo dyes and insoluble pigments used particularly in the textile, leather and paper industries. 2-Tolidine was widely used as a reagent or indicator in analytical, clinical and forensic chemistry, such as in the analytical determination of gold, or determination of the chlorine level in swimming pool water.
2-Tolidine is toxic and possibly carcinogenic. It is listed as an IARC Group 2B carcinogen, meaning it is "possibly carcinogenic to humans". Animal studies have shown that animals exposed to tolidine developed tumors in the liver, kidney, and mammary glands.
- Record of ortho-Tolidin in the GESTIS Substance Database of the IFA, accessed on 6.6.2008
- Noller, Carl R.: Textbook of Organic Chemistry, Springer Verlag, 1960
- K. Hunger. W. Herbst "Pigments, Organic" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2012. doi:10.1002/14356007.a20_371
- CDC - NIOSH Pocket Guide to Chemical Hazards