Tom Misteli, Ph.D. is a Swiss-born (Solothurn) cell biologist and pioneer in the field of genome cell biology. He is a Distinguished Investigator at the National Cancer Institute, NIH, Bethesda, MD, United States. He is the Director of the NCI Center for Cancer Research at the NIH. He was the Editor-in-Chief of The Journal of Cell Biology and is the current editor of Current Opinion in Cell Biology.
Tom Misteli is best known for his work on elucidation of how genomes function in living cells.[Ref 1] While a post-doc at the Cold Spring Harbor Laboratory, New York, United States, he developed methods to visualize proteins in the nucleus of living mammalian cells allowing for the first time to study gene expression in intact cells. His more recent work focuses on the role of genome organization and nuclear architecture on differentiation and disease. His cell biological elucidation of the mechanisms involved in the pre-mature aging disease Hutchinson–Gilford progeria syndrome have revealed novel mechanisms of human aging.[Ref 2] For his work he has won numerous awards including the Flemming Award, The Gold Medal of the Charles University, The Beerman Award, and the Feulgen Prize.
- Misteli Lab