Tonawanda High School is a public high school located in the City of Tonawanda, New York. It is part of the Tonawanda City School District. The school's football field was at one time the home of the Tonawanda Kardex, a professional football team, who achieved fame by playing in just one game as a member of the National Football League in 1921. The Kardex would sometimes draw up to 3,500 fans for a game. However NFL records list the nonexistent "Lumbermen Stadium" as the team's home field.
- 1941: Charles DeGlopper, Recipient of the Congressional Medal of Honor due his actions in World War II.
- 1942: Warren Muck, non-commissioned officer with Easy Company, 2nd Battalion, 506th Parachute Infantry Regiment, in the 101st Airborne Division during World War II.
- 1963: Rick Cassata, CFL quarterback
- 1973: Dave Geisel (1955- ), Major league baseball pitcher