Tony Kouzarides

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Tony Kouzarides
Born (1958-01-17) 17 January 1958 (age 61)[1]
Alma materUniversity of Leeds (BSc)
University of Cambridge (PhD)
AwardsHeinrich Wieland Prize (2013)
Fellow of the Royal Society (2012)[2]
FMedSci (2001)[3]
Scientific career
FieldsCancer
Chromatin
Transcription
InstitutionsUniversity of Leeds
University of Cambridge
Gurdon Institute
New York University
Laboratory of Molecular Biology
Abcam
ThesisA molecular analysis of transformation by human cytomegalovirus (1985)
Doctoral advisorTony Minson[4]
Websitewww.gurdon.cam.ac.uk/~kouzarideslab
royalsociety.org/people/tony-kouzarides

Tony Kouzarides, FMedSci,[3] FRS[2] (born 17 January 1958) is the deputy director of the Gurdon Institute,[5] a founding non-executive director of Abcam[6] and a Professor of Cancer Biology at the University of Cambridge.[7]

Education[edit]

Kouzarides was educated at the University of Leeds, graduating with a Bachelor of Science degree in Genetics in 1981.[1] He went on to complete his PhD at the University of Cambridge in 1985.[8]

Research[edit]

Following his PhD, Kouzarides did postdoctoral work at the Laboratory of Molecular Biology (LMB) on the cancer potential of cytomegalovirus[9] and then on to New York University Medical Center. Here he examined the c-Fos leucine zipper dimerisation domain to elucidate its function. He got a job at the Gurdon Institute in Cambridge, where he has been since.[10]

Kouzarides is a leader in the field of chromatin modification[11] and its role in transcriptional control and cancer.[12][13] In 1996 he made a key discovery in finding that the transcriptional co-activator CBP[14] is a histone acetyltransferase.[15][16] He has since worked on identifying several new histone modifications, describing their functions in transcription and DNA repair and highlighting their mis-regulation in cancer. His demonstration that a histone acetylation pathway inhibitor can be used to treat MLL-leukaemias has facilitated its use in clinical trials.[2]

Awards[edit]

Kouzarides was elected a member of the Academy of Medical Sciences (FMedSci) in 2001[3]. He received the Bijvoet Medal of the Bijvoet Center for Biomolecular Research of Utrecht University in 2008[17]. He was elected a Fellow of the Royal Society (FRS) in 2012.[2] His nomination read:

"Tony Kouzarides is world leader in the field of chromatin modification and its roles in transcriptional control and cancer. His finding in 1996 that the transcriptional co-activator CBP is a histone acetyltransferase was one of the key discoveries that started the modern era of chromatin research. His subsequent work has identified several new histone modifications, described their functions in transcription and DNA repair and has highlighted their mis-regulation in cancer. His demonstration that a histone acetylation pathway inhibitor is an effective treatment for MLL-leukaemias in disease models has opened the way to its use in clinical trials."[2]

Kouzarides was also awarded the Sanofi-Cell Research Outstanding Paper Award of 2011[18] for his paper on Regulation of chromatin by histone modifications co-authored with Andrew Bannister.[19]

In 2013, he was awarded the Heinrich Wieland Prize for his pioneering "research on gene regulation and cancer"[20]

References[edit]

  1. ^ a b "KOUZARIDES, Prof. Tony". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press. Retrieved 18 March 2015. (subscription required)
  2. ^ a b c d e "Professor Tony Kouzarides FMedSci FRS". Retrieved 24 April 2012.
  3. ^ a b c "The Academy of Medical Sciences | Directory of Fellows". Archived from the original on 6 June 2013.
  4. ^ Cranage, M. P.; Kouzarides, T.; Bankier, A. T.; Satchwell, S.; Weston, K.; Tomlinson, P.; Barrell, B.; Hart, H.; Bell, S. E.; Minson, A. C. (1986). "Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus". The EMBO Journal. 5 (11): 3057–3063. doi:10.1002/j.1460-2075.1986.tb04606.x. PMC 1167261. PMID 3024973.
  5. ^ "The Kouzarides Lab at the Gurdon Institute". Retrieved 24 April 2012.
  6. ^ "Abcam board of directors". Retrieved 24 April 2012.
  7. ^ "Professor Tony Kouzarides profile- Cambridge Cancer Centre". Archived from the original on 6 June 2013.
  8. ^ Kouzarides, Tony (1985). A molecular analysis of transformation by human cytomegalovirus (PhD thesis). University of Cambridge.
  9. ^ https://www.sciencemag.org/careers/2008/06/creativity-and-persistence-overcome-failure
  10. ^ "About Tony Kouzarides". Retrieved 24 April 2012.
  11. ^ Kouzarides, T. (2007). "Chromatin Modifications and Their Function". Cell. 128 (4): 693–705. doi:10.1016/j.cell.2007.02.005. PMID 17320507.
  12. ^ "Tony Kouzarides publications in Google Scholar". Retrieved 24 April 2012.
  13. ^ Search Results for author Kouzarides T on PubMed.
  14. ^ Bannister, A. J.; Kouzarides, T. (1996). "The CBP co-activator is a histone acetyltransferase". Nature. 384 (6610): 641–643. Bibcode:1996Natur.384..641B. doi:10.1038/384641a0. PMID 8967953.
  15. ^ Kouzarides, T.; Brehm, A.; Miska, E. A.; McCance, D. J.; Reid, J. L.; Bannister, A. J. (1998). "Retinoblastoma protein recruits histone deacetylase to repress transcription". Nature. 391 (6667): 597–601. Bibcode:1998Natur.391..597B. doi:10.1038/35404. PMID 9468139.
  16. ^ Santos-Rosa, H.; Schneider, R.; Bannister, A. J.; Sherriff, J.; Bernstein, B. E.; Emre, N. C. T.; Schreiber, S. L.; Mellor, J.; Kouzarides, T. (2002). "Active genes are tri-methylated at K4 of histone H3". Nature. 419 (6905): 407–411. Bibcode:2002Natur.419..407S. doi:10.1038/nature01080. PMID 12353038.
  17. ^ "Bijvoet Medal". Bijvoet Center for Biomolecular Research. Retrieved 12 September 2017.
  18. ^ Li, D. (2012). "Sanofi-Cell Research Outstanding Paper Award of 2011". Cell Research. 22 (11): 1511. doi:10.1038/cr.2012.153. PMC 3494390. PMID 23128785.
  19. ^ Bannister, A. J.; Kouzarides, Tony (2011). "Regulation of chromatin by histone modifications". Cell Research. 21 (3): 381–395. doi:10.1038/cr.2011.22. PMC 3193420. PMID 21321607.
  20. ^ Heinrich Wieland Prize. Retrieved 18 March 2015. ‹See Tfd›(in German)