Topterone

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Topterone
Topterone.svg
Clinical data
Routes of
administration
Topical
Identifiers
Synonyms WIN-17665; 17α-propyltestosterone; 17β-hydroxy-17α-propylandrost-4-en-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard 100.056.638
Chemical and physical data
Formula C22H34O2
Molar mass 330.50416 g/mol
3D model (Jmol)

Topterone (INN, USAN) (developmental code name WIN-17665), also known as 17α-propyltestosterone or 17α-propylandrost-4-en-17β-ol-3-one, is a steroidal antiandrogen that was first reported in 1978 and was developed for topical administration but, due to poor effectiveness, was never marketed.[1][2][3][4][5][6]

See also[edit]

References[edit]

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1–. ISBN 978-1-4757-2085-3. 
  2. ^ Ferrari, Richard A; Chakrabarty, Krishna; Beyler, Arthur L; Wiland, Julius (1978). "Suppression of Sebaceous Gland Development in Laboratory Animals by 17α-Propyltestosterone". Journal of Investigative Dermatology. 71 (5): 320–323. ISSN 0022-202X. doi:10.1111/1523-1747.ep12529809. 
  3. ^ Annual Reports in Medicinal Chemistry. Academic Press. 16 September 1986. pp. 183–. ISBN 978-0-08-058365-5. 
  4. ^ Ferrari RA, Chakrabarty K, Creange JE, Beyler AL, Potts OG, Schane HP (1980). "Endocrine profile of topterone, a topical antiandrogen, in three species of laboratory animals". Methods Find Exp Clin Pharmacol. 2 (2): 65–9. PMID 7339330. 
  5. ^ Chakrabarty, Krishna; Ferrari, Richard A.; Dessingue, Oksana C.; Beyler, Arthur L.; Schane, H. Philip (1980). "Mechanism of Action of 17α-Propyltestosterone in Inhibiting Hamster Flank Organ Development". Journal of Investigative Dermatology. 74 (1): 5–8. ISSN 0022-202X. doi:10.1111/1523-1747.ep12514560. 
  6. ^ Pharmacology of the Skin II: Methods, Absorption, Metabolism and Toxicity, Drugs and Diseases. Springer Science & Business Media. 6 December 2012. pp. 490–. ISBN 978-3-642-74054-1.