Torasemide

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Torasemide
Torasemide.svg
Torasemide bas.png
Systematic (IUPAC) name
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a601212
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Oral, IV
Legal status
Legal status
Pharmacokinetic data
Bioavailability 80-90%
Protein binding Highly bound (>99%).
Metabolism Hepatic (80%)
Biological half-life 3.5 hours; Cirrhosis: 7-8 hours
Identifiers
CAS Number 56211-40-6 YesY
ATC code C03CA04 (WHO)
PubChem CID 41781
IUPHAR/BPS 7312
DrugBank DB00214 YesY
ChemSpider 38123 YesY
UNII W31X2H97FB YesY
KEGG D00382 YesY
ChEBI CHEBI:9637 N
ChEMBL CHEMBL1148 YesY
Chemical data
Formula C16H20N4O3S
Molar mass 348.421 g/mol
 NYesY (what is this?)  (verify)

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand names Demadex, Diuver, and Examide.

Compared with other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium loss. No evidence of torasemide-induced ototoxicity has been demonstrated in humans.[1]

Recent publications suggest improved outcomes when used for heart failure compared with furosemide. . PMID 24243991.  Missing or empty |title= (help). PMID 25728721.  Missing or empty |title= (help). PMID 26704029.  Missing or empty |title= (help)

References[edit]

  1. ^ Dunn CJ, Fitton A, Brogden RN (January 1995). "Torasemide. An update of its pharmacological properties and therapeutic efficacy". Drugs 49 (1): 121–42. doi:10.2165/00003495-199549010-00009. PMID 7705212. 

External links[edit]