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Torasemide bas.png
Clinical data
Trade names Demadex, Tortas
Synonyms Torsemide (USAN US)
AHFS/ International Drug Names
MedlinePlus a601212
  • US: C (Risk not ruled out)
Routes of
Oral, IV
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 80-90%
Protein binding Highly bound (>99%).
Metabolism Hepatic (80%)
Biological half-life 3.5 hours; Cirrhosis: 7-8 hours
CAS Number
PubChem CID
ECHA InfoCard 100.164.924
Chemical and physical data
Formula C16H20N4O3S
Molar mass 348.421 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Torasemide or torsemide is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand names Demadex, Diuver, and Examide.

Compared with other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium loss. No evidence of torasemide-induced ototoxicity has been demonstrated in humans.[1]

Recent publications suggest improved outcomes when used for heart failure compared with furosemide.[2][3][4]


  1. ^ Dunn CJ, Fitton A, Brogden RN (January 1995). "Torasemide. An update of its pharmacological properties and therapeutic efficacy". Drugs. 49 (1): 121–42. doi:10.2165/00003495-199549010-00009. PMID 7705212. 
  2. ^ Roush GC, Kaur R, Ernst ME (2014). "Diuretics: a review and update". J. Cardiovasc. Pharmacol. Ther. 19 (1): 5–13. doi:10.1177/1074248413497257. PMID 24243991. 
  3. ^ Buggey J, Mentz RJ, Pitt B, Eisenstein EL, Anstrom KJ, Velazquez EJ, O'Connor CM (2015). "A reappraisal of loop diuretic choice in heart failure patients". Am. Heart J. 169 (3): 323–33. doi:10.1016/j.ahj.2014.12.009. PMC 4346710Freely accessible. PMID 25728721. 
  4. ^ Mentz RJ, Hasselblad V, DeVore AD, Metra M, Voors AA, Armstrong PW, Ezekowitz JA, Tang WH, Schulte PJ, Anstrom KJ, Hernandez AF, Velazquez EJ, O'Connor CM (2016). "Torsemide Versus Furosemide in Patients With Acute Heart Failure (from the ASCEND-HF Trial)". Am. J. Cardiol. 117 (3): 404–11. doi:10.1016/j.amjcard.2015.10.059. PMC 4718787Freely accessible. PMID 26704029. 

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