Toronto West Centre was a federal electoral district represented in the Canadian House of Commons from 1925 to 1935. It was located in the province of Ontario. This riding was created in 1924 from parts of Toronto Centre and Toronto West ridings.
It consisted of the part of the city of Toronto bounded on the north by Bloor Street, on the west by Dovercourt Road, on the south by Dundas Street, and on the east by Avenue Road, Queen's Park Crescent and University Avenue.
The electoral district was abolished in 1933 when it was redistributed between Spadina, St. Paul's and Trinity ridings.