Sonneborn attended the Baltimore City Public Schools and graduated from the Baltimore City College (high school) in 1922. As an adolescent, Sonneborn was interested in the humanities and considered becoming a rabbi. After taking a biology course taught by E. A. Andrews, his interest in literature was eclipsed by his interest in science. He earned a B.A. from Johns Hopkins University in 1925 and a Ph.D in 1928. His graduate work, supervised by Herbert S. Jennings, focused on the flatworm Stenostomum.
Sonneborn spent 1928 and 1929 researching the ciliate Colpidium with Jennings as a National Research Council fellow. He remained at Hopkins until 1939, with appointments as research assistant, research associate, and associate. He was offered a faculty position at Indiana University, where he served as associate professor, professor (1943), distinguished service professor (1953), and distinguished service professor emeritus (1976).
In the late 1950s he conducted a series of experiments in his endeavours to discover what it is that mediates the synchronised movement of the paramecium's cilia. These minuscule hair-like projections enable the cell to 'swim'. They move together and paddle the cell through the water in which it lives.
The paramecium is a single-cell organism, so has nothing remotely resembling a brain. Yet its cilia move together like dancers in a ballet. How is it that their movements are co-ordinated?
Sonneborn surgically removed a small section of cell wall and replaced it rotated by 180 degrees. The cortex with the cilia in the replaced section continued to 'wave' in the same direction as they had before surgery, i.e. now in antiphase to the others. What was remarkable is that both daughters of paramecium on which this operation had been performed also showed the same trait of a reverse phase wave if the reversal overlapped the division plane. If the reversed cortex did not overlap the division plane then only one the progeny had the inverted sequence. Cortical inheritance has major implications for what occurs in human (or any fertilized) egg divisions.
Sonneborn also showed the cytoplasmic inheritance of mitochondria and chloroplasts along with other internal cellular organelles (Kappa particles) which had their own DNA were inherited but limited by their distribution in the cytoplasm at the time of cell division. Only progeny from the 'half' of the cell with the mutant organelles inherited those organelles and thus the associated trait. Obviously, most cells had a distribution such that the organelles were in both halves but in cases where the new mutant arose and thus is rare then only those cell with cytoplasm containing the rare form inherited the traits associated with it.
It is a mark of his excellence as a scientist that he should have taken the trouble to follow the fate of subsequent generations and so be able to make these observation. It may seem surprising that the clear evidence for non-Mendelian inheritance should have been largely overlooked by the scientific community. It may also be that, as at that time the mechanisms of genetic inheritance in DNA were becoming open to investigation, this example of non-Mendelian inheritance was not of great interest to the scientific community. While non-mendelian inheritance is limited to the cortical structures and to the internal organelles with their own DNAk it does play a major role in some human disorders as well as "handiness" and the left/right orientation of the zygote. Very important factors.
Sonneborn as teacher
Sonneborn was an innovative teacher. He taught a course entitled Heredity, Evolution and Society that dealt with the science of genetics and the implications that technological advancements in that field held for society. One of his popular lectures involved students enacting the process of protein synthesis during which the genetic code is translated into the sequential addition of amino acids to form a polypeptide. His enthusiasm was infectious, and his lectures inspired students to study protozoa and algae.
Sonneborn married Ruth Meyers in 1929. Though educated as a social worker, she concentrated upon supporting her husband's career. They had two sons: Lee (1929–2004), a mathematician, and David (b. 1934), a biologist.
- Beale, G. H. (1982). "Tracy Morton Sonneborn. 19 October 1905-26 January 1981". Biographical Memoirs of Fellows of the Royal Society. 28: 537–574. doi:10.1098/rsbm.1982.0021. JSTOR 769910.
- Preer, J. R. Jr. Tracy Morton Sonneborn, National Academy of Sciences Biographical Memoirs
- Nanney, D. L. (1982). "Tracy M. Sonneborn (1905-1981)". Genetics. 102 (1): 1–7. PMID 6751933.
- Nanney, D. L. (1981). "T.M. Sonneborn: An Interpretation". Annual Review of Genetics. 15: 1–9. doi:10.1146/annurev.ge.15.120181.000245. PMID 6802065.
- Aufderheide, K. J. (1986). "Identification of the basal bodies and kinetodesmal fibers in living cells of Paramecium tetraurelia Sonneborn, 1975 and Paramecium sonneborni Aufderheide, Daggett & Nerad, 1983". The Journal of Protozoology. 33 (1): 77–80. doi:10.1111/j.1550-7408.1986.tb05561.x. PMID 3959010.
- Leonhart, James Chancellor (1939). One Hundred Years Of Baltimore City College. Baltimore: H.G. Roebuck & Son. p. 282.
- Preer, John R., Jr. Tracy Morton Sonneborn 1905-1981 (Washington, D.C.: National Academies Press, 1996), 271.
- Preer, 271-2.
- Preer, 273-4.
- Sonneborn Manuscripts at the Lilly Library Manuscript Collections