Tralokinumab

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Tralokinumab
Monoclonal antibody
Type Whole antibody
Source Human
Target IL13
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
Formula C6374H9822N1698O2014S44
Molar mass 143.87 kg/mol
 NYesY (what is this?)  (verify)

Tralokinumab is a human monoclonal antibody which targets the cytokine interleukin 13,[1] and is designed for the treatment of asthma and other inflammatory diseases.[2] Tralokinumab was discovered by Cambridge Antibody Technology scientists, using Ribosome Display, as CAT-354[3] and taken through pre-clinical and early clinical development.[4] After 2007 it has been developed by MedImmune, a member of the AstraZeneca group, where it is currently in Ph3 testing for asthma and Ph2b testing for atopic dermatitis.[5][6] This makes it one of the few fully internally discovered and developed drug candidates in AstraZeneca's late stage development pipeline.

Discovery and Development[edit]

Tralokinumab (CAT-354) was discovered by Cambridge Antibody Technology scientists[7] using protein optimization based on Ribosome Display.[8] They used the extensive data sets from ribosome display to patent protect CAT-354 in a world-first of sequence-activity-relationship claims.[7] In 2004, clinical development of CAT-354 was initiated with this first study completing in 2005.[9] On 21 July 2011, MedImmune LLC initiated a Ph2b, randomized, double-blind study to evaluate the efficacy of tralokinumab in adults with asthma.[10]

As of 2016, MedImmune and AstraZeneca are developing tralokinumab for asthma (Ph3) and atopic dermatitis (Ph2b) while clinical development for moderate-to-severe ulcerative colitis and idiopathic pulmonary fibrosis (IPF) have been discontinued.[9]

Tralokinumab was licensed to LEO Pharma for skin diseases in July 2016. [11]

References[edit]

  1. ^ Kopf, Manfred; Bachmann, Martin F.; Marsland, Benjamin J. (2010). "Averting inflammation by targeting the cytokine environment". Nature Reviews Drug Discovery. 9 (9): 703–18. PMID 20811382. doi:10.1038/nrd2805. 
  2. ^ "Statement On A Nonproprietary Name Adopted By The USAN Council: Tralokinumab" (PDF). American Medical Association. 
  3. ^ Thom, G; Cockroft, AC; Buchanan, AG; Candotti, CJ; Cohen, ES; Lowne, D; Monk; Shorrock-Hart, CP; Jermutus, L; Minter, RR. "Probing a protein–protein interaction by in vitro evolution" [P]. Proc. Natl. Acad. Sci. USA. 103: 7619–7624. PMC 1458619Freely accessible. PMID 16684878. doi:10.1073/pnas.0602341103. 
  4. ^ May, RD; Monk, PD; Cohen, ES; Manuel, D; Dempsey, F; Davis, NHE; Dodd, AJ; Corkill, DJ; et al. (2012). "Preclinical development of CAT-354, an IL-13 neutralizing antibody, for the treatment of severe uncontrolled asthma". British Journal of Pharmacology. 166 (1): 177–193. PMC 3415647Freely accessible. PMID 21895629. doi:10.1111/j.1476-5381.2011.01659.x. 
  5. ^ "Pipeline". MedImmune. Retrieved 11 June 2013. 
  6. ^ "Studies found for CAT-354". ClinicalTrials.gov. Retrieved 11 June 2013. 
  7. ^ a b Human Antibody Molecules for Il-13, retrieved 2015-07-26 
  8. ^ Jermutus, Lutz; Honegger, Annemarie; Schwesinger, Falk; Hanes, Jozef; Plückthun, Andreas (2001-01-02). "Tailoring in vitro evolution for protein affinity or stability". Proceedings of the National Academy of Sciences. 98 (1): 75–80. ISSN 0027-8424. PMC 14547Freely accessible. PMID 11134506. doi:10.1073/pnas.98.1.75. 
  9. ^ a b "Tralokinumab - AdisInsight". adisinsight.springer.com. Retrieved 2016-02-20. 
  10. ^ Clinical trial number NCT01402986 for "A Phase 2b, Randomized, Double-blind Study to Evaluate the Efficacy of Tralokinumab in Adults With Asthma" at ClinicalTrials.gov
  11. ^ https://www.astrazeneca.com/media-centre/press-releases/2016/astrazeneca-enters-licensing-agreements-with-leo-pharma-in-skin-diseases-01072016.html