Transcription elongation regulator 1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TCERG1
Protein TCERG1 PDB 1e0l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TCERG1, CA150, TAF2S, Urn1, transcription elongation regulator 1
External IDs MGI: 1926421 HomoloGene: 4879 GeneCards: TCERG1
RNA expression pattern
PBB GE TCERG1 202396 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040006
NM_006706

NM_001039474
NM_001289526

RefSeq (protein)

NP_001035095
NP_006697

NP_001034563.1
NP_001276455.1
NP_001034563
NP_001276455

Location (UCSC) Chr 5: 146.45 – 146.51 Mb Chr 18: 42.51 – 42.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.[3][4][5]

Function[edit]

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.[3]

Interactions[edit]

Transcription elongation regulator 1 has been shown to interact with SF1[6] and POLR2A.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: TCERG1 transcription elongation regulator 1". 
  4. ^ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology. 17 (10): 6029–39. PMC 232452Freely accessible. PMID 9315662. 
  5. ^ Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome : Official Journal of the International Mammalian Genome Society. 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711. 
  6. ^ Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. United States. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933Freely accessible. PMID 11604498. 
  7. ^ Carty, S M; Goldstrohm A C; Suñé C; Garcia-Blanco M A; Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (16): 9015–20. doi:10.1073/pnas.160266597. ISSN 0027-8424. PMC 16813Freely accessible. PMID 10908677. 

Further reading[edit]