Transcription initiation protein SPT3 homolog

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SUPT3H
Identifiers
Aliases SUPT3H, SPT3, SPT3L, SPT3 homolog, SAGA and STAGA complex component
External IDs MGI: 1923723 HomoloGene: 121570 GeneCards: SUPT3H
Genetically Related Diseases
attention deficit hyperactivity disorder[1]
RNA expression pattern
PBB GE SUPT3H 206506 s at fs.png

PBB GE SUPT3H 211106 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001261823
NM_003599
NM_181356

NM_178652

RefSeq (protein)

NP_001248752
NP_003590
NP_852001

n/a

Location (UCSC) Chr 6: 44.81 – 45.38 Mb Chr 17: 44.78 – 45.12 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.[4][5][6]

Interactions[edit]

Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,[7][8] TAF6L,[8] TADA3L,[8] TAF5L,[8] SF3B3,[8] SUPT7L,[8] Myc,[9] TAF9,[8] Transformation/transcription domain-associated protein,[8] TAF12,[8] TAF10,[7][8] TAF4[7] and DDB1.[8]

Model organisms[edit]

Model organisms have been used in the study of SUPT3H function. A conditional knockout mouse line called Supt3tm1a(EUCOMM)Hmgu was generated at the Wellcome Trust Sanger Institute.[10] Male and female animals underwent a standardized phenotypic screen[11] to determine the effects of deletion.[12][13][14][15] Additional screens performed: - In-depth immunological phenotyping[16]

References[edit]

  1. ^ "Diseases that are genetically associated with SUPT3H view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. 
  5. ^ Martinez E, Kundu TK, Fu J, Roeder RG (Sep 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry. 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987. 
  6. ^ "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)". 
  7. ^ a b c Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203Freely accessible. PMID 11406595. 
  8. ^ a b c d e f g h i j k Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856Freely accessible. PMID 11564863. 
  9. ^ Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917Freely accessible. PMID 12660246. 
  10. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  11. ^ a b "International Mouse Phenotyping Consortium". 
  12. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750. 
  13. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  14. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  15. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207Freely accessible. PMID 23870131. 
  16. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]