Transcriptional activator LAG-3

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PDB 2fo1 EBI.jpg
crystal structure of the csl-notch-mastermind ternary complex bound to dna
Symbol Activator_LAG-3
Pfam PF11498
InterPro IPR021587

In molecular biology, the transcriptional activator LAG-3 is a transcriptional activator protein. The C. elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12.[1] Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1.[1]


  1. ^ a b Petcherski AG, Kimble J (May 2000). "LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway". Nature. 405 (6784): 364–8. doi:10.1038/35012645. PMID 10830967. 

This article incorporates text from the public domain Pfam and InterPro IPR021587