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The translatome is composed of all mRNA fragments that are translated in a moment or condition in a single cell. Usually, the ribosome profiling technique is used to acquire the translatome information.[1] Other methods are polysome profiling, full-length translating mRNA profiling (RNC-seq), and translating ribosome affinity purification (TRAP-seq).[2]

Unlike the transcriptome, the translatome is a more accurate approximation for estimating the expression level of some genes, since the correlation between the proteome and translatome is higher than the correlation between the transcriptome and proteome.[3]


  1. ^ King HA, Gerber AP (January 2016). "Translatome profiling: methods for genome-scale analysis of mRNA translation". Briefings in Functional Genomics. 15 (1): 22–31. doi:10.1093/bfgp/elu045. PMID 25380596.
  2. ^ Zhao J, Qin B, Nikolay R, Spahn CM, Zhang G (January 2019). "Translatomics: The Global View of Translation". International Journal of Molecular Sciences. 20 (1): 212. doi:10.3390/ijms20010212. PMC 6337585. PMID 30626072.
  3. ^ Smircich P, Eastman G, Bispo S, Duhagon MA, Guerra-Slompo EP, Garat B, et al. (June 2015). "Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi". BMC Genomics. 16: 443. doi:10.1186/s12864-015-1563-8. PMC 4460968. PMID 26054634.