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The translatome is composed of all mRNA fragments that are translated in a moment or condition in a single cell. Usually, the ribosome profiling technique is used to acquire the translatome information. Other methods are polysome profiling, full-length translating mRNA profiling (RNC-seq), and translating ribosome affinity purification (TRAP-seq).
Unlike the transcriptome, the translatome is a more accurate approximation for estimating the expression level of some genes, since the correlation between the proteome and translatome is higher than the correlation between the transcriptome and proteome.
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