Translatome

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The translatome is composed of all mRNA fragments that are translated in a moment or condition in a single cell. Usually, the ribosome profiling technique is used to acquire the translatome information.[1]

Unlike the transcriptome, the translatome is a more accurate approximation for estimating the expression level of some genes, since the correlation between the proteome and translatome is higher than the correlation between the transcriptome and proteome.[2]

References[edit]

  1. ^ King, HA; Gerber, AP (2016). "Translatome profiling: methods for genome-scale analysis of mRNA translation". Brief Funct Genomics. 15 (1): 22–31. doi:10.1093/bfgp/elu045. PMID 25380596.
  2. ^ Smircich, P; Eastman, G; Bispo, S; Duhagon, MA; Guerra-Slompo, EP; Garat, B; Goldenberg, S; Munroe, DJ; Dallagiovanna, B; Holetz, F; Sotelo-Silveira, JR (2015). "Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi". BMC Genomics. 16: 443. doi:10.1186/s12864-015-1563-8. PMC 4460968. PMID 26054634.