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Transporter Classification Database

From Wikipedia, the free encyclopedia

The Transporter Classification Database (or TCDB) is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins, including ion channels.[1][2][3]


The upper level of classification and a few examples of proteins with known 3D structure:

1. Channels and pores[edit]

1.A α-type channels[edit]

1.B. β-Barrel porins and other outer membrane proteins[edit]

1.C Pore-forming toxins (proteins and peptides)[edit]

1.D Non-ribosomally synthesized channels[edit]

  • 1.D.1 The Gramicidin A Channel Family
  • 1.D.2 The Channel-forming Syringomycin Family
  • 1.D.3 The Channel-Forming Syringopeptin Family
  • 1.D.4 The Tolaasin Channel-forming Family
  • 1.D.5 The Alamethicin or Peptaibol Antibiotic Channel-forming Family
  • 1.D.6 The Complexed Poly 3-Hydroxybutyrate Ca2+ Channel (cPHB-CC) Family
  • 1.D.7 The Beticolin Family
  • 1.D.8 The Saponin Family
  • 1.D.9 The Polyglutamine Ion Channel (PG-IC) Family
  • 1.D.10 The Ceramide-forming Channel Family
  • 1.D.11 The Surfactin Family
  • 1.D.12 The Beauvericin (Beauvericin) Family
  • 1.D.13 DNA-delivery Amphipathic Peptide Antibiotics (DAPA)
  • 1.D.14 The Synthetic Leu/Ser Amphipathic Channel-forming Peptide (l/S-SCP) Family
  • 1.D.15 The Daptomycin (Daptomycin) Family
  • 1.D.16 The Synthetic Amphipathic Pore-forming Heptapeptide (SAPH) Family
  • 1.D.17 Combinatorially-designed, Pore-forming, β-sheet Peptide Family
  • 1.D.18 The Pore-forming Guanosine-Bile Acid Conjugate Family
  • 1.D.19 Ca2+ Channel-forming Drug, Digitoxin Family
  • 1.D.20 The Pore-forming Polyene Macrolide Antibiotic/fungal Agent (PMAA) Family
  • 1.D.21 The Lipid Nanopore (LipNP) Family
  • 1.D.22 The Proton-Translocating Carotenoid Pigment, Zeaxanthin Family
  • 1.D.23 Phenylene Ethynylene Pore-forming Antimicrobial (PEPA) Family
  • 1.D.24 The Marine Sponge Polytheonamide B (pTB) Family
  • 1.D.25 The Arylamine Foldamer (AAF) Family
  • 1.D.26 The Dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucoside (DDDC9G) Family
  • 1.D.27 The Thiourea isosteres Family
  • 1.D.28 The Lipopeptaibol Family
  • 1.D.29 The Macrocyclic Oligocholate Family
  • 1.D.30 The Artificial Hydrazide-appended pillar[5]arene Channels (HAPA-C) Family
  • 1.D.31 The Amphotericin B Family
  • 1.D.32 The Pore-forming Novicidin Family
  • 1.D.33 The Channel-forming Polytheonamide B Family
  • 1.D.34 The Channel-forming Oligoester Bolaamphiphiles
  • 1.D.35 The Pore-forming cyclic Lipodepsipeptide Family
  • 1.D.36 The Oligobornene Ion Channel Family
  • 1.D.37 The Hibicuslide C Family
  • 1.D.38 The Cyclic Peptide Nanotube (cPepNT) Family
  • 1.D.39 The Light-controlled Azobenzene-based Amphiphilic Molecular Ion Channel (AAM-IC) Family
  • 1.D.40 The Protein-induced Lipid Toroidal Pore Family
  • 1.D.41 The Sprotetonate-type Ionophore (Spirohexanolide) Family
  • 1.D.42 The Phe-Arg Tripeptide-Pillar[5]Arene Channel (TPPA-C) Family
  • 1.D.43 The Triazole-tailored Guanosine Dinucleoside Channel (TT-GDN-C) Family
  • 1.D.44 The Synthetic Ion Channel with Redox-active Ferrocene (ICRF) Family
  • 1.D.45 The Sonoporation and Electroporation Membrane Pore (SEMP) Family
  • 1.D.46 The DNA Nanopore (DnaNP) Family
  • 1.D.47 The Pore-forming Synthetic Cyclic Peptide (PSCP) Family
  • 1.D.48 The Pore-forming Syringomycin E Family
  • 1.D.49 The Transmembrane Carotenoid Radical Channel (CRC) Family
  • 1.D.50 The Amphiphilic bis-Catechol Anion Transporter (AC-AT) Family
  • 1.D.51 The Protein Nanopore (ProNP) Family
  • 1.D.52 The Aromatic Oligoamide Macrocycle Nanopore (OmnNP) Family
  • 1.D.53 The alpha, gamma-Peptide Nanotube (a,gPepNT) Family
  • 1.D.54 The potassium-selective Hexyl-Benzoureido-15-Crown-5-Ether Ion Channel (HBEC) Family
  • 1.D.55 The Porphyrin-based Nanopore (PorNP) Family
  • 1.D.56 The Alpha-Aminoisobutyrate (Aib) Oligomeric Nanopore (AibNP) Family
  • 1.D.57 The Lipid Electro-Pore (LEP) Family
  • 1.D.58 The Anion Transporting Prodigiosene (Prodigiosene) Family
  • 1.D.59 The Anion Transporting Perenosin (Perenosin) Family
  • 1.D.60 The Alpha,Gamma-Cyclic Peptide (AGCP) Family
  • 1.D.61 The Anionophoric 2,6-Bis(Benzimidazol-2-yl)Pyridine (ABBP) Family
  • 1.D.62 The Bis-Triazolyl DiGuanosine Derivative Channel-forming (TDG) Family
  • 1.D.63 The Peptide-based Nanopore (PepNP) Family
  • 1.D.64 The Carbon Nanotube (CarNT) Family
  • 1.D.65 The Pore-forming Amphidinol (Amphidinol) Family
  • 1.D.66 The Helical Macromolecule Nanopore (HmmNP) Family
  • 1.D.67 The Crown Ether-modified Helical Peptide Ion Channel (CEHP) Family
  • 1.D.68 The Pore-forming Pleuronic Block Polymer (PPBP) Family
  • 1.D.69 The Conical Nanopore (ConNP) Family
  • 1.D.70 The Metallic (Au/Ag/Pt/graphene) Nanopore (MetNP) Family
  • 1.D.71 The Synthetic TP359 Peptide (TP359) Family
  • 1.D.72 The Chloride Carrier Triazine-based Tripodal Receptor (CCTTR) Family
  • 1.D.73 The Mesoporous Silica Nanopore (SilNP) Family
  • 1.D.74 The Stimulus-responsive Synthetic Rigid p-Octiphenyl Stave Pore (SSROP) Family

1.E Holins[edit]

1.F Vesicle fusion pores[edit]

  • 1.F.1 The Synaptosomal Vesicle Fusion Pore (SVF-Pore) Family
  • 1.F.2 The Octameric Exocyst (Exocyst) Family

1.G Viral fusion pores[edit]

  • 1.G.1 The Viral Pore-forming Membrane Fusion Protein-1 (VMFP1) Family
  • 1.G.2 The Viral Pore-forming Membrane Fusion Protein-2 (VMFP2) Family
  • 1.G.3 The Viral Pore-forming Membrane Fusion Protein-3 (VMFP3) Family
  • 1.G.4 The Viral Pore-forming Membrane Fusion Protein-4 (VMFP4) Family
  • 1.G.5 The Viral Pore-forming Membrane Fusion Protein-5 (VMFP5) Family
  • 1.G.6 The Hepadnaviral S Fusion Protein (HBV-S Protein) Family
  • 1.G.7 The Reovirus FAST Fusion Protein (R-FAST) Family
  • 1.G.8 The Arenavirus Fusion Protein (AV-FP) Family
  • 1.G.9 The Syncytin (Syncytin) Family
  • 1.G.10 The Herpes Simplex Virus Membrane Fusion Complex (HSV-MFC) Family
  • 1.G.11 Poxvirus Cell Entry Protein Complex (PEP-C) Family
  • 1.G.12 The Avian Leukosis Virus gp95 Fusion Protein (ALV-gp95) Family
  • 1.G.13 The Orthoreovirus Fusion-associated Small Transmembrane (FAST) Family
  • 1.G.14 The Influenza Virus Hemagglutinin/Fusion Pore-forming Protein (Influenza-H/FPP) Family
  • 1.G.15 The Autographa californica Nuclear Polyhedrosis Virus Major Envelope Glycoprotein GP64 (GP64) Family
  • 1.G.16 The Human Immunodeficiency Virus Type 1 (HIV-1) Fusion Peptide (HIV-FP) Family
  • 1.G.17 The Bovine Leukemia Virus Envelop Glycoprotein (BLV-Env) Family
  • 1.G.18 The SARS-CoV Fusion Peptide in the Spike Glycoprotein Precursor (SARS-FP) Family
  • 1.G.19 The Rotavirus Pore-forming Membrane Fusion Complex (Rotavirus MFC) Family
  • 1.G.20 The Hantavirus Gc Envelope Fusion Glycoprotein (Gc-EFG) Family
  • 1.G.21 The Epstein Barr Virus (Human Herpes Virus 4) Gp42 (Gp42) Family
  • 1.G.22 The Cytomegalovirus (Human Herpesvirus 5) Glycoprotein gO (gO) Family

1.H Paracellular channels[edit]

  • 1.H.1 The Claudin Tight Junction (Claudin1) Family
  • 1.H.2 The Invertebrate PMP22-Claudin (Claudin2) Family

1.I Membrane-bound channels[edit]

2. Electrochemical potential-driven transporters[edit]

2.A Porters (uniporters, symporters, antiporters)[edit]

  • 2.A.1 Major Facilitator superfamily (MFS), see also Lactose permease, Phosphate permease and Glucose transporter
  • 2.A.2 The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family
  • 2.A.3 The Amino Acid-Polyamine-Organocation (APC) Family
  • 2.A.4 Cation diffusion facilitator (CDF) Family
  • 2.A.5 Zinc (Zn2+)-Iron (Fe2+) Permease Family
  • 2.A.6 Resistance-Nodulation-Cell Division Superfamily, see also SecDF protein-export membrane protein
  • 2.A.7 The Drug/Metabolite Transporter (DMT) Superfamily
  • 2.A.8 The Gluconate:H+ Symporter (GntP) Family
  • 2.A.9 The Membrane Protein Insertase (YidC/Alb3/Oxa1) Family
  • 2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family
  • 2.A.11 The Citrate-Mg2+:H+ (CitM) Citrate-Ca2+:H+ (CitH) Symporter (CitMHS) Family
  • 2.A.12 ATP:ADP Antiporter Family
  • 2.A.13 The C4-Dicarboxylate Uptake (Dcu) Family
  • 2.A.14 Lactate Permease Family
  • 2.A.15 The Betaine/Carnitine/Choline Transporter (BCCT) Family
  • 2.A.16 Tellurite-resistance/Dicarboxylate Transporter Family
  • 2.A.17 Proton-dependent Oligopeptide Transporter Family
  • 2.A.18 The Amino Acid/Auxin Permease (AAAP) Family
  • 2.A.19 The Ca2+:Cation Antiporter (CaCA) Family
  • 2.A.20 The Inorganic Phosphate Transporter (PiT) Family
  • 2.A.21 Solute:Sodium Symporter Family
  • 2.A.22 The Neurotransmitter:Sodium Symporter Family
  • 2.A.23 The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family
  • 2.A.24 The 2-Hydroxycarboxylate Transporter (2-HCT) Family
  • 2.A.25 Alanine or Glycine:Cation Symporter (AGCS) Family
  • 2.A.26 The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family
  • 2.A.27 The Glutamate:Na+ Symporter (ESS) Family
  • 2.A.28 Bile Acid:Na+ Symporter Family
  • 2.A.29 Mitochondrial carrier Family
  • 2.A.30 Cation-Chloride Cotransporter (CCC) Family
  • 2.A.31 Anion Exchanger Family
  • 2.A.32 The Silicon Transporter (Sit) Family
  • 2.A.33 NhaA Na+:H+ Antiporter (NhaA) Family
  • 2.A.34 The NhaB Na+:H+ Antiporter (NhaB) Family
  • 2.A.35 The NhaC Na+:H+ Antiporter (NhaC) Family
  • 2.A.36 Monovalent Cation:Proton Antiporter-1 (CPA1) Family
  • 2.A.37 Monovalent Cation:Proton Antiporter-2 (CPA2) Family
  • 2.A.38 K+ Transporter (Trk) Family
  • 2.A.39 Nucleobase:Cation Symporter-1 (NCS1) Family
  • 2.A.40 Nucleobase:Cation Symporter-2 (NCS2) Family
  • 2.A.41 The Concentrative Nucleoside Transporter (CNT) Family
  • 2.A.42 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
  • 2.A.43 The Lysosomal Cystine Transporter (LCT) Family
  • 2.A.45 Arsenite-Antimonite Efflux Family
  • 2.A.46 The Benzoate:H+ Symporter (BenE) Family
  • 2.A.47 Divalent Anion:Na+ Symporter (DASS) Family
  • 2.A.48 The Reduced Folate Carrier (RFC) Family
  • 2.A.49 Chloride Carrier/Channel (ClC) Family
  • 2.A.50 The Glycerol Uptake (GUP) Family
  • 2.A.51 The Chromate Ion Transporter (CHR) Family
  • 2.A.52 The Ni2+-Co2+ Transporter (NiCoT) Family
  • 2.A.53 Sulfate permease (SulP) Family
  • 2.A.54 The Mitochondrial Tricarboxylate Carrier (MTC) Family
  • 2.A.55 The Metal Ion (Mn2+-iron) Transporter (Nramp) Family
  • 2.A.56 The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family
  • 2.A.57 The Equilibrative Nucleoside Transporter (ENT) Family
  • 2.A.58 The Phosphate:Na+ Symporter (PNaS) Family
  • 2.A.59 The Arsenical Resistance-3 (ACR3) Family
  • 2.A.60 Organo Anion Transporter (OAT) Family
  • 2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family
  • 2.A.62 The NhaD Na+:H+ Antiporter (NhaD) Family
  • 2.A.63 The Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family
  • 2.A.64 Twin Arginine Targeting (Tat) Family
  • 2.A.65 The Bilirubin Transporter (BRT) Family
  • 2.A.66 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily
  • 2.A.67 The Oligopeptide Transporter (OPT) Family
  • 2.A.68 The p-Aminobenzoyl-glutamate Transporter (AbgT) Family
  • 2.A.69 The Auxin Efflux Carrier (AEC) Family
  • 2.A.70 The Malonate:Na+ Symporter (MSS) Family
  • 2.A.71 The Folate-Biopterin Transporter (FBT) Family
  • 2.A.72 The K+ Uptake Permease (KUP) Family
  • 2.A.73 The Short Chain Fatty Acid Uptake (AtoE) Family
  • 2.A.74 The 4 TMS Multidrug Endosomal Transporter (MET) Family
  • 2.A.75 The L-Lysine Exporter (LysE) Family
  • 2.A.76 The Resistance to Homoserine/Threonine (RhtB) Family
  • 2.A.77 The Cadmium Resistance (CadD) Family
  • 2.A.78 The Branched Chain Amino Acid Exporter (LIV-E) Family
  • 2.A.79 The Threonine/Serine Exporter (ThrE) Family
  • 2.A.80 The Tricarboxylate Transporter (TTT) Family
  • 2.A.81 The Aspartate:Alanine Exchanger (AAEx) Family
  • 2.A.82 The Organic Solute Transporter (OST) Family
  • 2.A.83 The Na+-dependent Bicarbonate Transporter (SBT) Family
  • 2.A.84 The Chloroplast Maltose Exporter (MEX) Family
  • 2.A.85 The Aromatic Acid Exporter (ArAE) Family
  • 2.A.86 The Autoinducer-2 Exporter (AI-2E) Family (Formerly the PerM Family, TC #9.B.22)
  • 2.A.87 The Prokaryotic Riboflavin Transporter (P-RFT) Family
  • 2.A.88 Vitamin Uptake Transporter (VUT or ECF) Family
  • 2.A.89 The Vacuolar Iron Transporter (VIT) Family
  • 2.A.90 Vitamin A Receptor/Transporter (STRA6) Family
  • 2.A.91 Mitochondrial tRNA Import Complex (M-RIC) (Formerly 9.C.8)
  • 2.A.92 The Choline Transporter-like (CTL) Family
  • 2.A.94 The Phosphate Permease (Pho1) Family
  • 2.A.95 The 6TMS Neutral Amino Acid Transporter (NAAT) Family
  • 2.A.96 The Acetate Uptake Transporter (AceTr) Family
  • 2.A.97 The Mitochondrial Inner Membrane K+/H+ and Ca2+/H+ Exchanger (LetM1) Family
  • 2.A.98 The Putative Sulfate Exporter (PSE) Family
  • 2.A.99 The 6TMS Ni2+ uptake transporter (HupE-UreJ) Family
  • 2.A.100 The Ferroportin (Fpn) Family
  • 2.A.101 The Malonate Uptake (MatC) Family (Formerly UIT1)
  • 2.A.102 The 4-Toluene Sulfonate Uptake Permease (TSUP) Family
  • 2.A.103 The Bacterial Murein Precursor Exporter (MPE) Family
  • 2.A.104 The L-Alanine Exporter (AlaE) Family
  • 2.A.105 The Mitochondrial Pyruvate Carrier (MPC) Family
  • 2.A.106 The Ca2+:H+ Antiporter-2 (CaCA2) Family
  • 2.A.107 The MntP Mn2+ Exporter (MntP) Family
  • 2.A.108 The Iron/Lead Transporter (ILT) Family
  • 2.A.109 The Tellurium Ion Resistance (TerC) Family
  • 2.A.110 The Heme Transporter, heme-responsive gene protein (HRG) Family
  • 2.A.111 The Na+/H+ Antiporter-E (NhaE) Family
  • 2.A.112 The KX Blood-group Antigen (KXA) Family
  • 2.A.113 The Nickel/cobalt Transporter (NicO) Family
  • 2.A.114 The Putative Peptide Transporter Carbon Starvation CstA (CstA) Family
  • 2.A.115 The Novobiocin Exporter (NbcE) Family
  • 2.A.116 The Peptidoglycolipid Addressing Protein (GAP) Family
  • 2.A.117 The Chlorhexadine Exporter (CHX) family
  • 2.A.118 The Basic Amino Acid Antiporter (ArcD) Family
  • 2.A.119 The Organo-Arsenical Exporter (ArsP) Family
  • 2.A.120 The Putative Amino Acid Permease (PAAP) Family
  • 2.A.121 The Sulfate Transporter (CysZ) Family
  • 2.A.122 The LrgB/CidB holin-like auxiliary protein (LrgB/CidB) Family
  • 2.A.123 The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family
  • 2.A.124 The Lysine Exporter (LysO) Family
  • 2.A.125 The Eukaryotic Riboflavin Transporter (E-RFT) Family
  • 2.A.126 The Fatty Acid Exporter (FAX) Family
  • 2.A.127 Enterobacterial Cardiolipin Transporter (CLT) Family

2.B Nonribosomally synthesized porters[edit]

  • 2.B.1 The Valinomycin Carrier Family
  • 2.B.2 The Monensin Family
  • 2.B.3 The Nigericin Family
  • 2.B.4 The Macrotetrolide Antibiotic (MA) Family
  • 2.B.5 The Macrocyclic Polyether (MP) Family
  • 2.B.6 The Ionomycin Family
  • 2.B.7 The Transmembrane α-helical Peptide Phospholipid Translocation (TMP-PLT) Family
  • 2.B.8 The Bafilomycin A1 (Bafilomycin) Family
  • 2.B.9 The Cell Penetrating Peptide (CPP) Functional Family
  • 2.B.10 The Synthetic CPP, Transportan Family
  • 2.B.11 The Calcimycin or A23187 Carrier-type Ionophore Family
  • 2.B.12 The Salinomycin Family
  • 2.B.13 The Tetrapyrrolic Macrocyclic Anion Antiporter (TPMC-AA) Family
  • 2.B.14 The Lasalocid A or X-537A Ionophore (Lasalocid) Family
  • 2.B.15 The Tris-thiourea Tripodal-based Chloride Carrier (TTT-CC) Family
  • 2.B.16 The Halogen-bond-containing Compound Anion Carrier (HCAC) Family
  • 2.B.17 The Isophthalaminde Derivative H+:Cl Co-transporter (IDC) Family
  • 2.B.18 The Pyridine-2,6-Dicarboxamine Derivative (PDCA) H+:Cl Co-transporter Family
  • 2.B.19 The Calix(4)pyrrole Derivative (C4P) Family
  • 2.B.20 The Prodigiosin (Prodigiosin) Chloride/Bicarbonate Exchanger Family
  • 2.B.21 The ortho-Phenylenediamine-bis-Urea Derivative Anion Transporter (oPDA-U) Family
  • 2.B.22 The Imidazolium-functionalized Anion Transporter (IAT) Family
  • 2.B.23 The Homotetrameric Transmembrane Zn2+/Co2+:Proton Synthetic Antiporter, Rocker (Rocker) Family
  • 2.B.24 The 2,6-Bis(benzimidazol-2-yl)pyridine Anion Carrier (BBP-AC) Family
  • 2.B.25 The Peptide-mediated Lipid Flip-Flop (PLFF) Family
  • 2.B.26 The Bis(imidazolyl)-functionalized Bis(Choloyl) Conjugate (BIBCC) Family
  • 2.B.27 The Tris-Urea Anion Transporter Family
  • 2.B.29 The Anionophoric Marine Alkaloid Tambjamine Family

2.C Ion-gradient-driven energizers[edit]

  • 2.C.1 The TonB-ExbB-ExbD/TolA-TolQ-TolR (TonB) Family of Auxiliary Proteins for Energization of Outer Membrane Receptor (OMR)-mediated Active Transport

3. Primary active transporters[edit]

3.A. P-P-bond hydrolysis-driven transporters[edit]

  • 3.A.1 ABC transporters including BtuCD, molybdate uptake transporter, Cystic fibrosis transmembrane conductance regulator and others
  • 3.A.2 The H+- or Na+-translocating F-type ATPase, V-type ATPase and A-type ATPase superfamily
  • 3.A.3 The P-type ATPase Superfamily
  • 3.A.4 The Arsenite-Antimonite efflux family
  • 3.A.5 General secretory pathway (Sec) translocon (preprotein translocase SecY)
  • 3.A.6 The Type III (Virulence-related) Secretory Pathway (IIISP) Family
  • 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
  • 3.A.8 The Mitochondrial Protein Translocase (MPT) Family
  • 3.A.9 The Chloroplast Envelope Protein Translocase (CEPT or Tic-Toc) Family
  • 3.A.10 H+, Na+-translocating Pyrophosphatase family
  • 3.A.11 The Bacterial Competence-related DNA Transformation Transporter (DNA-T) Family
  • 3.A.12 The Septal DNA Translocator (S-DNA-T) Family
  • 3.A.13 The Filamentous Phage Exporter (FPhE) Family
  • 3.A.14 The Fimbrilin/Protein Exporter (FPE) Family
  • 3.A.15 The Outer Membrane Protein Secreting Main Terminal Branch (MTB) Family
  • 3.A.16 The Endoplasmic Reticular Retrotranslocon (ER-RT) Family
  • 3.A.17 The Phage T7 Injectisome (T7 Injectisome) Family
  • 3.A.18 The Nuclear mRNA Exporter (mRNA-E) Family
  • 3.A.19 The TMS Recognition/Insertion Complex (TRC) Family
  • 3.A.20 The Peroxisomal Protein Importer (PPI) Family
  • 3.A.21 The C-terminal Tail-Anchored Membrane Protein Biogenesis/ Insertion Complex (TAMP-B) Family
  • 3.A.22 The Transcription-coupled TREX/TAP Nuclear mRNA Export Complex (TREX) Family
  • 3.A.23 The Type VI Symbiosis/Virulence Secretory Pathway (VISP) Family
  • 3.A.24 Type VII or ESX Protein Secretion System (T7SS) Family
  • 3.A.25 The Symbiont-specific ERAD-like Machinery (SELMA) Family
  • 3.A.26 The Plasmodium Translocon of Exported proteins (PTEX) Family

3.B Decarboxylation-driven transporters[edit]

  • 3.B.1 The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family

3.C Methyltransfer-driven transporters[edit]

  • 3.C.1 The Na+ Transporting Methyltetrahydromethanopterin:Coenzyme M Methyltransferase (NaT-MMM) Family

3.D. Oxidoreduction-driven transporters[edit]

They include a number of transmembrane cytochrome b-like proteins including coenzyme Q - cytochrome c reductase (cytochrome bc1 ); cytochrome b6f complex; formate dehydrogenase, respiratory nitrate reductase; succinate - coenzyme Q reductase (fumarate reductase); and succinate dehydrogenase. See electron transport chain.

  • 3.D.1 The H+ or Na+-translocating NADH Dehydrogenase ("complex I") family
  • 3.D.2 The Proton-translocating Transhydrogenase (PTH) Family
  • 3.D.3 The Proton-translocating Quinol:Cytochrome c Reductase) Superfamily
  • 3.D.4 Proton-translocating Cytochrome Oxidase (COX) Superfamily
  • 3.D.5 The Na+-translocating NADH:Quinone Dehydrogenase (Na-NDH or NQR) Family
  • 3.D.6 The Putative Ion (H+ or Na+)-translocating NADH:Ferredoxin Oxidoreductase (NFO or RNF) Family
  • 3.D.7 The H2:Heterodisulfide Oxidoreductase (HHO) Family
  • 3.D.8 The Na+- or H+-Pumping Formyl Methanofuran Dehydrogenase (FMF-DH) Family
  • 3.D.9 The H+-translocating F420H2 Dehydrogenase (F420H2DH) Family
  • 3.D.10 The Prokaryotic Succinate Dehydrogenase (SDH) Family

3.E. Light absorption-driven transporters[edit]

4. Group translocators[edit]

4.A Phosphotransfer-driven group translocators[edit]

4.B Nicotinamide ribonucleoside uptake transporters[edit]

  • 4.B.1 The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family

4.C Acyl CoA ligase-coupled transporters[edit]

  • 4.C.1 The Proposed Fatty Acid Transporter (FAT) Family
  • 4.C.2 The Carnitine O-Acyl Transferase (CrAT) Family
  • 4.C.3 The Acyl-CoA Thioesterase (AcoT) Family

4.D Polysaccharide Synthase/Exporters[edit]

  • 4.D.1 The Putative Vectorial Glycosyl Polymerization (VGP) Family
  • 4.D.2 The Glycosyl Transferase 2 (GT2) Family
  • 4.D.3 The Glycan Glucosyl Transferase (OpgH) Family

4.E. Vacuolar Polyphosphate Polymerase-catalyzed Group Translocators[edit]

  • 4.E.1 The Vacuolar (Acidocalcisome) Polyphosphate Polymerase (V-PPP) Family

5. Transport electron carriers[edit]

5.A Transmembrane 2-electron transfer carriers[edit]

  • 5.A.1 The Disulfide Bond Oxidoreductase D (DsbD) Family
  • 5.A.2 The Disulfide Bond Oxidoreductase B (DsbB) Family
  • 5.A.3 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family

5.B Transmembrane 1-electron transfer carriers[edit]

  • 5.B.1 The Phagocyte (gp91phox) NADPH Oxidase Family
  • 5.B.2 The Eukaryotic Cytochrome b561 (Cytb561) Family
  • 5.B.3 The Geobacter Nanowire Electron Transfer (G-NET) Family
  • 5.B.4 The Plant Photosystem I Supercomplex (PSI) Family
  • 5.B.5 The Extracellular Metal Oxido-Reductase (EMOR) Family
  • 5.B.6 The Transmembrane Epithelial Antigen Protein-3 Ferric Reductase (STEAP) Family
  • 5.B.7 The YedZ (YedZ) Family
  • 5.B.8 The Trans-Outer Membrane Electron Transfer Porin/Cytochrome Complex (ET-PCC) Family
  • 5.B.9 The Porin-Cytochrome c (Cyc2) Family

8. Accessory factors involved in transport[edit]

8.A Auxiliary transport proteins[edit]

8.B Ribosomally synthesized protein/peptide toxins that target channels and carriers[edit]

8.C Non-ribosomally synthesized toxins that target channels and carriers[edit]

9. Incompletely characterized transport systems[edit]

9.A Recognized transporters of unknown biochemical mechanism[edit]

9.B Putative transport proteins[edit]

9.C Functionally characterized transporters lacking identified sequences[edit]


  1. ^ Saier, Milton H.; Reddy, Vamsee S.; Tamang, Dorjee G.; Västermark, Åke (January 2014). "The Transporter Classification Database". Nucleic Acids Research. 42 (D1): D251–D258. doi:10.1093/nar/gkt1097. PMC 3964967. PMID 24225317.
  2. ^ Saier, M. H.; Yen, M. R.; Noto, K.; Tamang, D. G.; Elkan, C. (1 January 2009). "The Transporter Classification Database: recent advances". Nucleic Acids Research. 37 (Database): D274–D278. doi:10.1093/nar/gkn862. PMC 2686586. PMID 19022853.
  3. ^ Saier, M. H.; Tran, C. V.; Barabote, R. D. (1 January 2006). "TCDB: the Transporter Classification Database for membrane transport protein analyses and information". Nucleic Acids Research. 34 (90001): D181–D186. doi:10.1093/nar/gkj001. PMC 1334385. PMID 16381841.

External links[edit]