Trapidil

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Trapidil
Trapidil.svg
Clinical data
Trade names Rocornal, Avantrin, Travisco
AHFS/Drugs.com International Drug Names
Routes of
administration
By mouth
ATC code
Legal status
Legal status
  • US: Not approved
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard 100.035.834 Edit this at Wikidata
Chemical and physical data
Formula C10H15N5
Molar mass 205.26 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Trapidil is a vasodilator and an antiplatelet drug.[1][2] It also acts as an antagonist of platelet-derived growth factor.[3]

References[edit]

  1. ^ Büyükafşar, K; Yazar, A; Düşmez, D; Oztürk, H; Polat, G; Levent, A (October 2001). "Effect of Trapidil, an Antiplatelet and Vasodilator Agent on Gentamicin-Induced Nephrotoxicity in Rats". Pharmacological Research. 44 (4): 321–8. doi:10.1006/phrs.2001.0864. PMID 11592868. 
  2. ^ Liu, M; Sun, Q; Wang, Q; Wang, X; Lin, P; Yang, M; Yan, Y (March–April 2014). "Effect of Trapidil in Myocardial Ischemia-Reperfusion Injury in Rabbit". Indian Journal of Pharmacology. 46 (2): 207–10. doi:10.4103/0253-7613.129320. PMC 3987192Freely accessible. PMID 24741195. 
  3. ^ Maresta, A; Balducelli, M; Cantini, L; Casari, A; Chioin, R; Fabbri, M; Fontanelli, A; Monici Preti, PA; Repetto, S; De Servi, S (December 1994). "Trapidil (triazolopyrimidine), a Platelet-Derived Growth Factor Antagonist, Reduces Restenosis After Percutaneous Transluminal Coronary Angioplasty. Results of the Randomized, Double-Blind STARC Study". Circulation. 90 (6): 2710–5. doi:10.1161/01.cir.90.6.2710. PMID 7994812.