Tremorine

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Tremorine
Tremorine.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C12H20N2
Molar mass 192.300
3D model (JSmol)

Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs.[1][2][3][4][5] Beta blockers are also effective in counteracting the effects of tremorine.[6]

References[edit]

  1. ^ Trautner, E. M.; Gershon, S. (1959). "Use of 'Tremorine' for screening Anti-Parkinsonian Drugs". Nature. 183 (4673): 1462–1463. PMID 13657170. doi:10.1038/1831462a0. 
  2. ^ Friedman, A. H.; Aylesworth, R. J.; Friedman, G. (1963). "Tremorine: Its Effect on Amines of the Central Nervous System". Science. 141 (3586): 1188–1190. PMID 14043364. doi:10.1126/science.141.3586.1188. 
  3. ^ Menon, M.; Clark, W. G.; Aures, D. (1971). "Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats". Pharmacological Research Communications. 3 (4): 345. doi:10.1016/0031-6989(71)90005-1. 
  4. ^ Shinozaki, H.; Hirate, K.; Ishida, M. (1985). "Further studies on quantification of drug-induced tremor in mice: Effects of antitremorgenic agents on tremor frequency". Experimental neurology. 88 (2): 303–315. PMID 3987859. doi:10.1016/0014-4886(85)90193-1. 
  5. ^ Morais, L.; Quintansjunior, L.; Franco, C.; Almeida, J.; Almeida, R. (2004). "Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology". Pharmacology Biochemistry and Behavior. 79 (4): 745–749. PMID 15582683. doi:10.1016/j.pbb.2004.10.004. 
  6. ^ Paul, V. (1986). "The role of adrenergic mechanism in tremorine-induced tremors in rats: Antitremor effect of beta-adrenoceptor antagonists". Indian journal of physiology and pharmacology. 30 (4): 307–312. PMID 2883120. 

See also[edit]