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Treponematosis is a term used to individually describe any of the diseases caused by four members of the bacterial genus Treponema. The four diseases are collectively referred to as treponematoses:[1]

  • Syphilis (Treponema pallidum pallidum)
  • Yaws (Treponema pallidum pertenue)
  • Bejel (Treponema pallidum endemicum)
  • Pinta (Treponema carateum)

Traditional laboratory tests cannot distinguish the treponematoses.[2] However, sequence differences among the T. pallidum subspecies have been identified. Molecular approaches involving PCR to identify these sequences are being developed.[3]


  1. ^ Giacani, L.; Lukehart, S. A. "The Endemic Treponematoses". Clinical Microbiology Reviews. 27 (1): 89–115. doi:10.1128/CMR.00070-13. PMC 3910905. PMID 24396138.
  2. ^ Marks M, Solomon AW, Mabey DC (October 2014). "Endemic treponemal diseases". Transactions of the Royal Society of Tropical Medicine and Hygiene. 108 (10): 601–7. doi:10.1093/trstmh/tru128. PMC 4162659. PMID 25157125.
  3. ^ Mitjà O, Šmajs D, Bassat Q (2013). "Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta". PLoS Neglected Tropical Diseases. 7 (10): e2283. doi:10.1371/journal.pntd.0002283. PMC 3812090. PMID 24205410.

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