Pryce was selected by the Denver Broncos in the first round (28th overall) in the 1997 NFL Draft. In his rookie season he played in eight games and recorded 24 tackles and two sacks. He made his NFL debut on November 2 versus the Seattle Seahawks. In his second year with the Broncos, he started 15 out of the 16 games and made 43 tackles and a then career high 8.5 sacks. He was also a member of the Broncos' back-to-back championship teams, winning Super Bowl XXXII and Super Bowl XXXIII team. In the 1999 season he started in 15 games and recorded 46 tackles and a career high 13 sacks. He also earned his first trip to the Pro Bowl. The following season, 2000, he started all 16 regular season games and finished the season with 46 tackles and 12 sacks. He was also voted to his second consecutive Pro Bowl. In 2001, he was voted to his third consecutive Pro Bowl after finishing the season with 41 tackles and seven sacks. The 2002 season saw Pryce voted to the Pro Bowl for the fourth year in a row after finishing the campaign with 46 tackles and nine sacks. In 2003 he started in all 16 games including his 100th career game and recorded 36 tackles and 8.5 sacks. The 2004 season was a frustrating one for Pryce as he only played in two games after surgery on a herniated disc in his lower back. In his last year with the Broncos, Pryce started 16 times and recorded 33 tackles and four sacks.
In 2009, although no longer a member of the franchise, Pryce was named to the Broncos' 50th Anniversary Team; he took out an ad in the Denver Post thanking fans for the honor.
Pryce was signed by the Baltimore Ravens as a free agent on March 14, 2006. In his first season with the Ravens, he started in all 16 games and finished the season 47 tackles and 13 sacks which equaled his career-high. His play was a huge part of the Ravens' defense ranking #1 overall in 2006, and also had a franchise record of 60 regular season team sacks. In 2007, he made 15 tackles and two sacks, missing most of the season due to injury.
In the 2008 season, he made 27 tackles and 4.5 sacks.
In the 2009 season, he finished with 31 tackles, 6.5 sacks, and 1 forced fumble. He was not a full-time starter this year, splitting time with his 2007 replacement, Dwan Edwards.