Tribendimidine
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| Formula | C28H32N6 |
| Molar mass | 452.594 g/mol |
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Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.[1]
In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.[2] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.[1] The drug has also performed well in trials against opisthorchiasis, curing about 70% of cases.[3]
Tribendimidine is manufactured by Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China. It was approved by the China Food and Drug Administration in 2007.
References[edit]
- ^ a b Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J (2007). "Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini". Antimicrob Agents Chemother. 51 (3): 1096–8. doi:10.1128/AAC.01366-06. PMC 1803157. PMID 17194822. Free full text.
- ^ Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (2005). "Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China". Acta Trop. 94 (1): 1–14. doi:10.1016/j.actatropica.2005.01.013. PMID 15777691.
- ^ "New drug shows promise against Asian liver fluke". 2010-11-24.
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