Trifolium pratense (red clover) is a herbaceous species of flowering plant in the bean family Fabaceae, native to Europe, Western Asia and northwest Africa, but planted and naturalised in many other regions.
It is a herbaceous, short-lived perennial plant, variable in size, growing to 20–80 cm tall. The leaves are alternate, trifoliate (with three leaflets), each leaflet 15–30 mm long and 8–15 mm broad, green with a characteristic pale crescent in the outer half of the leaf; the petiole is 1–4 cm long, with two basal stipules that are abruptly narrowed to a bristle-like point. The flowers are dark pink with a paler base, 12–15 mm long, produced in a dense inflorescence.
It is widely grown as a fodder crop, valued for its nitrogen fixation, which increases soil fertility. For these reasons, it is used as a green manure crop. Several cultivar groups have been selected for agricultural use, mostly derived from T. pratense var. sativum. It has become naturalised in many temperate areas, including the Americas and Australasia as an escape from cultivation.
In alternative medicine, red clover is promoted as a treatment for a variety of human maladies, including coughs, disorders of the lymphatic system and a variety of cancers. However, according to the American Cancer Society, "available clinical evidence does not show that red clover is effective in treating or preventing cancer, menopausal symptoms, or any other medical conditions".
Dietary amounts of red clover are safe, but medicinal quantities may cause rash-like reactions, muscle ache, headache, nausea, vaginal bleeding in women, and slow blood clotting.
Red clover contains coumestrol, a phytoestrogen. Due to its activity on oestrogen receptors, red clover is contraindicated in people with a history of breast cancer, endometriosis, ovarian cancer, uterine cancer, uterine fibroids or other oestrogen-sensitive conditions, although some authors have suggested the high isoflavone content counteracts this, and even provides benefits in these conditions.
Red clover is subject to bacterial as well as fungal diseases, including the red clover rust, Uromyces trifolii-repentis var. fallens. Other problems include parasitic nematodes (roundworms) and viruses.
- "BSBI List 2007". Botanical Society of Britain and Ireland. Archived from the original (xls) on 2015-02-25. Retrieved 2014-10-17.
- "Red Clover Tea". SupplementSOS.com. Retrieved 2013-03-09.
- Limei Wang, Birgit Waltenberger, Eva-Maria Pferschy-Wenzig, Martina Blunder, Xin Liu, Clemens Malainer, Tina Blazevic, Stefan Schwaiger, Judith M. Rollinger, Elke H. Heiss, Daniela Schuster, Brigitte Kopp, Rudolf Bauer, Hermann Stuppner, Verena M. Dirsch & Atanas G. Atanasov (2014). "Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review". Biochemical Pharmacology 92 (1): 73–89. doi:10.1016/j.bcp.2014.07.018. PMID 25083916.
- "Red Clover". American Cancer Society. November 2008. Retrieved 22 September 2013.
- Red clover, WebMD.
- Bhagwat, Seema; Haytowitz, David; Holden, Joanne. "USDA Database for the Isoflavone Content of Selected Foods" (PDF). US Department of Agriculture. Retrieved 26 April 2015.
- Cornelia Bodinet & Johannes Freudenstein (2004). "Influence of marketed herbal menopause preparations on MCF-7 cell proliferation". Menopause 11 (3): 281–289. PMID 15167307.
- Dean W. Roberts, Daniel R. Doerge, Mona I. Churchwell, Gonçalo Gamboa da Costa, M. Matilde Marques & William H. Tolleson (2004). "Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover)". Journal of Agricultural and Food Chemistry 52 (21): 6623–6632. doi:10.1021/jf049418x. PMID 15479032.
- W. Abebe (2002). "Herbal medication: potential for adverse interactions with analgesic drugs". Journal of Clinical Pharmacy and Therapeutics 27 (6): 391–401. doi:10.1046/j.1365-2710.2002.00444.x. PMID 12472978.
- "Red clover (Trifolium pratense) Cautions - Epocrates Online". Online.epocrates.com. Retrieved 5 August 2012.
- "Other National Symbols". Embassy of Denmark, Washington DC. Archived from the original on 17 May 2007. Retrieved 3 April 2015.
- "Red Clover". Vermont Historical Society. Retrieved 3 April 2015.
- Vleugels, Tim; Roldan-Ruiz, Isabel; Cnops, Gerda (April 8, 2014). "Influence of flower and flowering characteristics on seed yield in diploid and tetraploid red clover". Plant Breeding 134 (1): 56-61. doi:10.1111/pbr.12224.
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|Wikiversity has bloom time data for Trifolium pratense on the Bloom Clock|