Trimethadione

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This article is about the drug Tridione. For the content management software Tridion, see SDL plc.
Trimethadione
Trimethadione.svg
Systematic (IUPAC) name
3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione
Clinical data
Trade names Tridione
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy
category
  • X
Routes of
administration
By mouth
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Bioavailability High
Metabolism Demethylated to dimethadione
Biological half-life 12–24 hours (trimethadione)
6–13 days (dimethadione)
Excretion Renal
Identifiers
CAS Number 127-48-0 YesY
ATC code N03AC02 (WHO)
PubChem CID 5576
IUPHAR/BPS 7316
DrugBank DB00347 YesY
ChemSpider 5374 YesY
UNII R7GV3H6FQ4 YesY
KEGG D00392 YesY
ChEMBL CHEMBL695 YesY
Chemical data
Formula C6H9NO3
Molar mass 143.141 g/mol
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Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

Fetal trimethadione syndrome[edit]

If administered during pregnancy, fetal trimethadione syndrome may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects, intrauterine growth restriction (IUGR), and mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[1]

References[edit]

External links[edit]