Trimethadione

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Trimethadione
Trimethadione.svg
Clinical data
Trade namesTridione
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • X
Routes of
administration
By mouth
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityHigh
MetabolismDemethylated to dimethadione
Elimination half-life12–24 hours (trimethadione)
6–13 days (dimethadione)
ExcretionRenal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.004.406 Edit this at Wikidata
Chemical and physical data
FormulaC6H9NO3
Molar mass143.141 g/mol
3D model (JSmol)
  (verify)

Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

Fetal trimethadione syndrome[edit]

If administered during pregnancy, fetal trimethadione syndrome may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects, intrauterine growth restriction (IUGR), and mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[1]

References[edit]

External links[edit]