Trimethylamine-N-oxide reductase

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trimethylamine-N-oxide reductase
EC number
CAS number 37256-34-1
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a trimethylamine-N-oxide reductase (EC is an enzyme that catalyzes the chemical reaction

NADH + H+ + trimethylamine N-oxide NAD+ + trimethylamine + H2O

The 3 substrates of this enzyme are NADH, H+, and trimethylamine N-oxide, whereas its 3 products are NAD+, trimethylamine, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a nitrogenous group as acceptor. The systematic name of this enzyme class is NADH:trimethylamine-N-oxide oxidoreductase. Other names in common use include trimethylamine N-oxide reductase, trimethylamine oxide reductase, TMAO reductase, and TOR. This enzyme participates in methane metabolism.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1TMO.


  • Unemoto T, Hayashi M, Miyaki K, Hayashi M (1965). "Intracellular localization and properties of trimethylamine-N-oxide reductase in Vibrio parahaemolyticus". Biochim. Biophys. Acta. 110 (2): 319–28. doi:10.1016/s0926-6593(65)80039-x. PMID 4286289.