Trimethylamine-corrinoid protein Co-methyltransferase

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Trimethylamine-corrinoid protein Co-methyltransferase
Identifiers
EC number 2.1.1.250
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Trimethylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.250, mttB (gene), trimethylamine methyltransferase) is an enzyme with systematic name trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

trimethylamine + [Co(I) trimethylamine-specific corrinoid protein] [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

This enzyme is involved in methanogenesis from trimethylamine.

References[edit]

  1. ^ Ferguson, D.J. Jr.; Krzycki, J.A. (1997). "Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri". J. Bacteriol. 179: 846–852. PMID 9006042. 
  2. ^ Krzycki, J.A. (2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Curr. Opin. Chem. Biol. 8: 484–491. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490. 

External links[edit]