Trimethylamine-corrinoid protein Co-methyltransferase
|Trimethylamine-corrinoid protein Co-methyltransferase|
|PDB structures||RCSB PDB PDBe PDBsum|
Trimethylamine-corrinoid protein Co-methyltransferase (EC 22.214.171.124, mttB (gene), trimethylamine methyltransferase) is an enzyme with systematic name trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase. This enzyme catalyses the following chemical reaction
- trimethylamine + [Co(I) trimethylamine-specific corrinoid protein] [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine
This enzyme is involved in methanogenesis from trimethylamine.
- Ferguson, D.J. Jr.; Krzycki, J.A. (1997). "Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri". J. Bacteriol. 179: 846–852. doi:10.1128/jb.179.3.846-852.1997. PMC . PMID 9006042.
- Krzycki, J.A. (2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Curr. Opin. Chem. Biol. 8: 484–491. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490.
- Trimethylamine---corrinoid protein Co-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)