2,4,6-Trinitrobenzenesulfonic acid

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2,4,6-Trinitrobenzene Sulfonic Acid
Trinitrobenzenesulfonic acid.png
2,4,6-Trinitrobenzenesulfonic acid molecule
Names
IUPAC name
2,4,6-Trinitrobenzenesulfonic acid
Other names
Picrylsulfonic acid; Trinitrobenzene sulfonate; TNBS
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.017.925
UN number 0386
Properties
C6H3N3O9S
Molar mass 293.16 g·mol−1
Density 0.955 g/cm3
Hazards
R-phrases (outdated) R11 R36/38
S-phrases (outdated) S16 S26 S33 S37/39
NFPA 704
Flammability code 4: Will rapidly or completely vaporize at normal atmospheric pressure and temperature, or is readily dispersed in air and will burn readily. Flash point below 23 °C (73 °F). E.g., propane Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 4: Readily capable of detonation or explosive decomposition at normal temperatures and pressures. E.g., nitroglycerin Special hazard OX: Oxidizer. E.g., potassium perchlorateNFPA 704 four-colored diamond
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Trinitrobenzenesulfonic acid (C6H3N3O9S) is an nitroaryl oxidizing acid. Due to its extreme oxidative properties, if mixed with reducing agents including hydrides, sulfides, and nitrides, it may begin a vigorous reaction that culminates in almost immediate detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents because of the explosive tendencies of aromatic nitro compounds which increase in the presence of multiple nitro groups. Not much is known about this compound, but it is used as a peptide terminal amino group neutralizer and is currently being investigated for its effects on the immune system.[1]

Uses[edit]

Its primary usage is primarily to neutralize peptide terminal amino groups in scientific research.[2] Occasionally it is used as a detonator for certain other explosive compounds.

It is also used to induce Crohn's Disease in the colon of laboratory animals in order to model Inflammatory Bowel Disease.

Health concerns and safety precautions[edit]

The primary hazard of working with 2,4,6-trinitrobenzenesulfonic acid is the risk of instantaneous explosion. 2,4,6-Trinitrobenzenesulfonic acid is an extremely sensitive compound especially when mixed with other compounds, exposed to heat, or exposed to rapid temperature or pressure changes. The toxicological properties of this compound has not been investigated, so all health effects are unknown. To best prevent bodily harm or injury its recommended that all direct contact be avoided and the compound be kept under extremely strict environmentally controlled conditions. In case of spillage its recommended that a local fire department be called in advance prior to any attempt at cleaning. In case of fire its recommended that the material is left to burn and the surrounding area is evacuated. If fire fighting is required its recommended that a fully positive pressure self-contained breathing apparatus is used along with either foam or CO2 extinguishers.[3][4]

References[edit]