3D model (JSmol)
|Molar mass||386.64 g·mol−1|
|Appearance||White, opaque crystals|
|Melting point||50 to 54 °C (122 to 129 °F; 323 to 327 K)|
|Boiling point||411.2 °C (772.2 °F; 684.3 K) at 760 mmHg|
|R-phrases (outdated)||R38, R41|
|S-phrases (outdated)||S26, S39|
|Flash point||110 °C (230 °F; 383 K)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Trioctylphosphine oxide (TOPO) is an organophosphorus compound with the formula OP(C8H17)3. Frequently referred to as TOPO, this compound is used as an extraction or stabilizing agent. It is an air-stable white solid at room temperature.
Preparation and use
TOPO is usually prepared by oxidation of trioctylphosphine, which in turn is produced by alkylation of phosphorus trichloride.
The main use of TOPO is in solvent extraction of metals, especially uranium. The high lipophilicity and high polarity are properties key to this application. Its high polarity, which results from the dipolar phosphorus-oxygen bond, allows this compound to bind to metal ions. The octyl groups confer solubility in low polarity solvents such as kerosene.
In the research laboratory, both trioctylphosphine and TOPO are frequently useful as a capping ligand for the production of quantum dots such as those consisting of CdSe. In these cases, TOPO serves as solvent for the synthesis and solubilizes the growing nanoparticles. TOPO-coated quantum dots are typically soluble in chloroform, toluene, and (to a lesser extent) hexane. These quantum dots are also used in biological applications as part of the protective barrier to prevent degradation as it travels through the harsh climate of the body.
- Nakhutin, I. E. (1971). Zhurnal Obshchei Khimii. 41 (5): 940–943. Missing or empty
- Watson, E. K.; Rickelton, W. A. "A review of the industrial and recent potential applications of trioctylphosphine oxide" Solvent Extraction and Ion Exchange 1992, volume 10, pp. 879-89. doi:10.1080/07366299208918141