Tripamide

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Tripamide
Tripamide.png
Systematic (IUPAC) name
3-(aminosulfonyl)-4-chloro-N-[(3aR,4S,7R,7aS)-octahydro-2H-4,7-methanoisoindol-2-yl]benzamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
  • (Prescription only)
Routes of
administration
Oral
Identifiers
CAS Number 73803-48-2
ATC code None
PubChem CID 636401
UNII G36A0E9CVT YesY
ChEMBL CHEMBL2104484
Chemical data
Formula C16H20ClN3O3S
Molar mass 369.86
  (verify)

Tripamide (INN) is a diuretic.

Synthesis[edit]

Tripamide synthesis:[1]

Preparation starts by exhaustive reduction of the Diels-Alder adduct from cyclopentadiene and maleimide (1). Nitrosation of the product (2), followed by reduction of the nitroso group of 3, gives the corresponding hydrazine (4). Acylation with acid chloride 5 gives tripamide (6).

References[edit]