Tripeptidyl peptidase II

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TPP2
Identifiers
Aliases TPP2, TPP-2, TPPII, Tripeptidyl peptidase II, tripeptidyl peptidase 2, TPP-II
External IDs MGI: 102724 HomoloGene: 2471 GeneCards: TPP2
Gene location (Human)
Chromosome 13 (human)
Chr. Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for TPP2
Genomic location for TPP2
Band 13q33.1 Start 102,597,003 bp[1]
End 102,679,958 bp[1]
RNA expression pattern
PBB GE TPP2 203374 s at fs.png

PBB GE TPP2 203375 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003291
NM_001330588

NM_009418
NM_001310540

RefSeq (protein)

NP_001317517
NP_003282

NP_001297469
NP_033444

Location (UCSC) Chr 13: 102.6 – 102.68 Mb Chr 1: 43.93 – 44 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2 gene.[5][6] Among other things it is heavily implicated in MHC (HLA) class-I processing, as it has both endopeptidase and exopeptidase activity.[7]


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134900 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041763 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Tomkinson B, Jonsson AK (Feb 1991). "Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin". Biochemistry. 30 (1): 168–74. doi:10.1021/bi00215a025. PMID 1670990. 
  6. ^ "Entrez Gene: TPP2 tripeptidyl peptidase II". 
  7. ^ Reits E, Neijssen J, Herberts C, et al. (April 2004). "A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation". Immunity. 20 (4): 495–506. doi:10.1016/S1074-7613(04)00074-3. PMID 15084277. 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S08.090

Further reading[edit]