Tripeptidyl peptidase II

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TPP2
Identifiers
Aliases TPP2, TPP-2, TPPII, Tripeptidyl peptidase II, tripeptidyl peptidase 2
External IDs MGI: 102724 HomoloGene: 2471 GeneCards: 7174
RNA expression pattern
PBB GE TPP2 203374 s at tn.png

PBB GE TPP2 203375 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003291

NM_009418
NM_001310540

RefSeq (protein)

NP_003282.2

NP_001297469.1
NP_033444.1

Location (UCSC) Chr 13: 102.6 – 102.68 Mb Chr 1: 43.93 – 44 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2 gene.[3][4] Among other things it is heavily implicated in MHC (HLA) class-I processing, as it has both endopeptidase and exopeptidase activity.[5]


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tomkinson B, Jonsson AK (Feb 1991). "Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin". Biochemistry. 30 (1): 168–74. doi:10.1021/bi00215a025. PMID 1670990. 
  4. ^ "Entrez Gene: TPP2 tripeptidyl peptidase II". 
  5. ^ Reits E, Neijssen J, Herberts C, et al. (April 2004). "A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation". Immunity. 20 (4): 495–506. doi:10.1016/S1074-7613(04)00074-3. PMID 15084277. 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S08.090

Further reading[edit]