Unit cell of tripotassium phosphate.
|Systematic IUPAC name
Potassium phosphate, tribasic
3D model (JSmol)
|E number||E340(iii) (antioxidants, ...)|
CompTox Dashboard (EPA)
|Molar mass||212.27 g/mol|
|Appearance||White deliquescent powder|
|Density||2.564 g/cm3 (17 °C)|
|Melting point||1,380 °C (2,520 °F; 1,650 K)|
|90 g/100 mL (20 °C)|
|Solubility in ethanol||Insoluble|
|Pnma, No. 62|
a = 1.123772 nm, b = 0.810461 nm, c = 0.592271 nm
|Safety data sheet||MSDS|
|NFPA 704 (fire diamond)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Tripotassium phosphate can be produced by the reaction of ammonium phosphate () with potassium chloride ().
Use in organic chemistry
Tripotassium phosphate has few applications except as a basic reagent in organic synthesis. It has been used as a catalyst for certain organic reactions.
Tripotassium phosphate has been used a catalyst for many organic reactions. It is cost-effective and has been used as an efficient catalyst to replace more expensive alternatives. Some of the reactions catalysed by are listed below:
- Hydrated tripotassium phosphate () can be used as a catalyst for the removal of BOC protecting group from secondary BOC amines using methanol as a solvent. Microwave radiation is used to aid the reaction.
- is used as a catalyst for the synthesis of unsymmetrical diaryl ethers using [Bmim] as the solvent. Aryl methane-sulfonates are deprotected and then followed by a nucleophilic aromatic substitution (SNAr) with activated aryl halides.
- was found to be one of the catalysts that aids in the coupling reaction of aryl halides with terminal alkynes. It also plays a role in the deacetonation of 4-aryl-2-methylbut-3-yn-2-ol intermediates.
- can be used as one of the catalysts for the addition of aryl halides to phenols and aliphatic alcohols.
Tripotassium phosphate is strongly basic.
- Voronin, V. I.; Ponosov, Yu. S.; Berger, I. F.; Proskurnina, N. V.; Zubkov, V. G.; Tyutyunnik, A. P.; Bushmeleva, S. N.; Balagurov, A. M.; Sheptyakov, D. V.; Burmakin, E. I.; Shekhtman, G. Sh.; Vovkotrub, E. G. (2006). "Crystal structure of the low-temperature form of K3PO4". Inorganic Materials. 42 (8): 908–913. doi:10.1134/S0020168506080206.
- "Potassium phosphate tribasic P5629". Sigma-Aldrich. Retrieved 2018-04-27.
- Klaus Schrödter; Gerhard Bettermann; Thomas Staffel; Friedrich Wahl; Thomas Klein; Thomas Hofmann (2012). "Phosphoric Acid and Phosphates". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_465.pub3.
- Cyclic process for producing tripotassium phosphate and ammonium chloride, 1968-10-15, retrieved 2018-04-27
- Dandepally, Srinivasa Reddy; Williams, Alfred L. (2009-03-04). "Microwave-assisted N-Boc deprotection under mild basic conditions using K3PO4·H2O in MeOH". Tetrahedron Letters. 50 (9): 1071–1074. doi:10.1016/j.tetlet.2008.12.074. ISSN 0040-4039.
- Xu, Hui; Chen, Yang (2007-04-30). "C(aryl)-O Bond Formation from Aryl Methanesulfonates via Consecutive Deprotection and SNAr Reactions with Aryl Halides in an Ionic Liquid". Molecules. 12 (4): 861–867. doi:10.3390/12040861. PMC 6149384.
- Shirakawa, Eiji; Kitabata, Takaaki; Otsuka, Hidehito; Tsuchimoto, Teruhisa (2005-10-10). "A simple catalyst system for the palladium-catalyzed coupling of aryl halides with terminal alkynes". Tetrahedron. 61 (41): 9878–9885. doi:10.1016/j.tet.2005.07.099. ISSN 0040-4020.
- Niu, Jiajia; Zhou, Hua; Li, Zhigang; Xu, Jingwei; Hu, Shaojing (2008-10-03). "An Efficient Ullmann-Type C−O Bond Formation Catalyzed by an Air-Stable Copper(I)−Bipyridyl Complex". The Journal of Organic Chemistry. 73 (19): 7814–7817. doi:10.1021/jo801002c. ISSN 0022-3263. PMID 18771324.