Triprolidine

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Triprolidine
Triprolidine.svg
Clinical data
Trade names Actidil, Myidil, Actifed,Recofast plus (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin)
AHFS/Drugs.com Monograph
Pregnancy
category
  • C (US)
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 4% oral
Protein binding 90%
Metabolism Hepatic (CYP2D6)
Elimination half-life 4–6 hours
Excretion Renal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.006.934 Edit this at Wikidata
Chemical and physical data
Formula C19H22N2
Molar mass 278.391 g/mol
3D model (JSmol)
Melting point 60 °C (140 °F)
Solubility in water 500 mg/mL (20 °C)
 ☒N☑Y (what is this?)  (verify)

Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] Like many antihistamines, the most common side effect is drowsiness.[1]

References[edit]

  1. ^ a b Goldsmith, P.; Dowd, P. M. (1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic clinics. 11 (1): 87–95. PMID 8094649.
  2. ^ Williams, B. O.; Liao, S. H.; Lai, A. A.; Arnold, J. D.; Perkins, J. G.; Blum, M. R.; Findlay, J. W. (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical pharmacy. 3 (6): 638–643. PMID 6509877.