|Trade names||Decapeptyl, Gonapeptyl, others|
|AHFS/Drugs.com||Micromedex Detailed Consumer Information|
|Drug class||GnRH analogue; GnRH agonist; Antigonadotropin|
|Chemical and physical data|
|Molar mass||1311.5 g/mol|
|3D model (JSmol)|
|(what is this?)|
Triptorelin, sold under the brand names Decapeptyl and Gonapeptyl among others, is a medication that causes stimulation of the pituitary, thus decreasing secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH).
It is also used in the UK, in conjunction with estradiol valerate, as part of hormone replacement therapy, to suppress testosterone in transgender people. It can help to relieve gender dysphoria caused by the physiological and psychological impact of testosterone on the body. It can prevent the advancement of androgen-related hair loss, soften the skin, and enable estrogen to have a more pronounced effect on breast growth and other fat redistribution. Spironolactone and cyproterone acetate are other drugs used by trans people to suppress testosterone, but these drugs have a completely different mechanism of action.
Society and culture
Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson Pharmaceuticals as Trelstar. In Iran Triptorelin is marketed under the brand name Variopeptyl.
- Lahlou N, Carel JC, Chaussain JL, Roger M (July 2000). "Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics". J Pediatr Endocrinol Metab. 13 Suppl 1: 723–37. PMID 10969915.
- Padula AM (August 2005). "GnRH analogues—agonists and antagonists". Anim Reprod Sci. 88 (1–2): 115–26. doi:10.1016/j.anireprosci.2005.05.005. PMID 15955640.