Triptorelin

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Triptorelin
Triptorelin.png
Clinical data
Trade names Decapeptyl, Gonapeptyl, others
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy
category
  • X
Drug class GnRH analogue; GnRH agonist; Antigonadotropin
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Excretion Kidney
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.165.044 Edit this at Wikidata
Chemical and physical data
Formula C64H82N18O13
Molar mass 1311.5 g/mol
3D model (JSmol)
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Triptorelin, sold under the brand names Decapeptyl and Gonapeptyl among others, is a medication that causes stimulation of the pituitary, thus decreasing secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH).

It is a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2) and a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts.

Medical uses[edit]

Triptorelin is used to treat prostate cancer.[1]

It is also used in the UK, in conjunction with estradiol valerate, as part of hormone replacement therapy, to suppress testosterone in transgender people. It can help to relieve gender dysphoria caused by the physiological and psychological impact of testosterone on the body. It can prevent the advancement of androgen-related hair loss, soften the skin, and enable estrogen to have a more pronounced effect on breast growth and other fat redistribution. Spironolactone and cyproterone acetate are other drugs used by trans people to suppress testosterone, but these drugs have a completely different mechanism of action.[2]

Triptorelin has been used as a chemical castration agent for reducing sexual urges in sex offenders.[3]

Society and culture[edit]

Brand names[edit]

Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson Pharmaceuticals as Trelstar. In Iran Triptorelin is marketed under the brand name Variopeptyl.

See also[edit]

References[edit]

  1. ^ "triptorelin (Intramuscular route)". drugs.com. Retrieved 11 November 2016. 
  2. ^ [[cite|web|title=Information About Hormonal Treatments for Transgender Women|accessdate=16 June 2018}}
  3. ^ Study: Drug effectively treats pedophilia, CNN, February 11, 1998.
  • Lahlou N, Carel JC, Chaussain JL, Roger M (July 2000). "Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics". J Pediatr Endocrinol Metab. 13 Suppl 1: 723–37. PMID 10969915. 
  • Padula AM (August 2005). "GnRH analogues—agonists and antagonists". Anim Reprod Sci. 88 (1–2): 115–26. doi:10.1016/j.anireprosci.2005.05.005. PMID 15955640.