Triptorelin

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Triptorelin
Triptorelin.png
Clinical data
Trade namesDecapeptyl, Gonapeptyl, others
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • X
Drug classGnRH analogue; GnRH agonist; Antigonadotropin
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
ExcretionKidney
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.165.044 Edit this at Wikidata
Chemical and physical data
FormulaC64H82N18O13
Molar mass1311.5 g/mol
3D model (JSmol)
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Triptorelin, sold under the brand names Decapeptyl and Gonapeptyl among others, is a medication that causes stimulation of the pituitary, thus decreasing secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

It is a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2) and a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts.

Medical uses[edit]

Triptorelin is used to treat prostate cancer.[1]

Another common use in the United Kingdom is for hormone replacement therapy to suppress testosterone in transgender people in conjunction with estradiol valerate. It can help to relieve gender dysphoria caused by the physiological and psychological impact of testosterone on the body. It can prevent the advancement of androgen-related hair loss, soften the skin, and enable estrogen to have a more pronounced effect on breast growth and other fat redistribution. Spironolactone and cyproterone acetate are other drugs used by trans people to suppress testosterone, but these drugs have a completely different mechanism of action.[2]

Triptorelin has been used as a chemical castration agent for reducing sexual urges in sex offenders.[3]

Society and culture[edit]

Brand names[edit]

Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson Pharmaceuticals as Trelstar. In Iran, triptorelin is marketed under the brand name Variopeptyl.

See also[edit]

References[edit]

  1. ^ "triptorelin (Intramuscular route)". drugs.com. Retrieved 11 November 2016.
  2. ^ [not_given "Information About Hormonal Treatments for Transgender Women"] Check |url= value (help). Retrieved 16 June 2018.
  3. ^ Study: Drug effectively treats pedophilia, CNN, February 11, 1998.

Further reading[edit]

  • Lahlou N, Carel JC, Chaussain JL, Roger M (July 2000). "Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics". J Pediatr Endocrinol Metab. 13 Suppl 1: 723–37. PMID 10969915.
  • Padula AM (August 2005). "GnRH analogues—agonists and antagonists". Anim Reprod Sci. 88 (1–2): 115–26. doi:10.1016/j.anireprosci.2005.05.005. PMID 15955640.