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Trixie may refer to:
- Trixie Friganza (1870–1955), American vaudeville performer and stage and silent film actress
- Trixie Gardner, Baroness Gardner of Parkes (born 1927), Australian-born British politician, dentist and peeress
- Trixie Maristela (born 1985), Filipino transgender actress
- Trixie Minx (born 1981), American burlesque dancer
- Trixi Schuba (born 1951), Austrian figure skater
- Trixie Smith (1895–1943), African American blues singer, vaudeville entertainer and actress
- Trixie Tagg, Australian soccer player and coach
- Trixie Whitley (born 1987), Belgian American multi-instrumentalist
- Trixie Mattel, American drag queen and winner of RuPaul's Drag Race All Stars season 3
- Thelma Norton, a character in the series The Honeymooners, is nicknamed Trixie
- Trixie, a character in the series Speed Racer
- Trixie, a character in the series Deadwood
- Trixie, a character in the series LazyTown
- Trixie, a triceratops toy in the film Toy Story 3
- Trixie Belden, the title character of a series of mysteries
- Trixie Lorraine, a character in the movie Gold Diggers of 1933 portrayed by Aline MacMahon
- Trixie Sting, a character in Slugterra
- Trixie Tang, a character in the series The Fairly OddParents
- Trixie Lulamoon, a character in the series My Little Pony: Friendship Is Magic
- Trixie Carter, a character in the series American Dragon: Jake Long
- Trixie Tucker, a character in the Australian television soap opera Neighbours'
- Trixie Franklin, a character in Call the Midwife played by Helen George
- Trixie, a female cat in Top Cat: The Movie
- Trixie, the infant daughter in the comic strip Hi and Lois
- Beatrice "Trixie" Espinoza, a character in the American television series, Lucifer.
- Trixie (film), a 2000 American mystery-crime film
- Trixie Film, producer of the Burn to Shine DVD series
- A fictional virus in the 1973 film The Crazies and its 2010 remake, alternatively titled Code Name: Trixie
- A working title of Star Wars: The Rise of Skywalker
| disambiguation page lists articles associated with the title Trixie.
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