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Skeletal formula
Clinical data
Trade names Viru-Merz
AHFS/ International Drug Names
Routes of
Topical (gel)
ATC code
Legal status
Legal status
  • US: Not FDA-approved
  • OTC (RU)
CAS Number
PubChem CID
ECHA InfoCard 100.053.409
Chemical and physical data
Formula C16H28N2O2
Molar mass 280.406 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.[1][2]

Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.


Tromantadine inhibits the early and late events in the virus replication cycle.[3] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.


  1. ^ Ostheimer, K. E.; Busch, T.; Görtelmeyer, R.; Hahn, K. D. (September 1989). "Randomized double-blind trial of tromantadine versus aciclovir in recurrent herpes orofacialis". Arzneimittel-Forschung. 39 (9): 1152–1155. ISSN 0004-4172. PMID 2686658. 
  2. ^ Diezel, W.; Michel, G.; Görtelmeyer, R.; Ostheimer, K. E. (April 1993). "Efficacy of tromantadine and aciclovir in the topical treatment of recurrent herpes orofacialis. Comparison in a clinical trial". Arzneimittel-Forschung. 43 (4): 491–496. ISSN 0004-4172. PMID 8494582. 
  3. ^ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6. PMC 185716Freely accessible. PMID 6297383. doi:10.1128/aac.22.6.1031. 

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