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Skeletal formula
Systematic (IUPAC) name
Clinical data
Trade names Viru-Merz
AHFS/ International Drug Names
Routes of
Topical (gel)
Legal status
Legal status
  • US: Not FDA-approved
  • OTC (RU)
CAS Number 53783-83-8 N
ATC code D06BB02 (WHO) J05AC03 (WHO)
PubChem CID 64377
ChemSpider 57947 YesY
KEGG D07199 YesY
NIAID ChemDB 007760
Chemical data
Formula C16H28N2O2
Molar mass 280.406 g/mol
 NYesY (what is this?)  (verify)

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.

Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.


Tromantadine inhibits the early and late events in the virus replication cycle.[1] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.


  1. ^ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6. doi:10.1128/aac.22.6.1031. PMC 185716free to read. PMID 6297383. 

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