Tropane alkaloid

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The chemical structure of tropane

Tropane alkaloids are a class of bicyclic [3.2.1] alkaloids and secondary metabolites that contain a tropane ring in their chemical structure.[1] Tropane alkaloids occur naturally in many members of the plant family Solanaceae. Some tropane alkaloids have pharmacological properties and can act as anticholinergics or stimulants.

Anticholinergics[edit]

Anticholinergic drugs[2] and deliriants:

All three acetylcholine-inhibiting chemicals can also be found in the leaves, stems, and flowers in varying, unknown amounts in Brugmansia (Angel Trumpets or Devil's Weed), a relative of Datura.

Stimulants[edit]

Stimulants and cocaine-related alkaloids:

Others[edit]

Non-natural tropanes[edit]

There exist some synthetic analogs of tropane alkaloids, see

They are not considered to be alkaloids per definition.

See also[edit]

References[edit]

  1. ^ O’Hagan, David (2000). "Pyrrole, pyrrolidine, pyridine, piperidine and tropane alkaloids (1998 to 1999)". Natural Product Reports 17 (5): 435–446. doi:10.1039/a707613d. 
  2. ^ Grynkiewicz, G; Gadzikowska, M. "Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs.". Pharmacological reports : PR 60 (4): 439–63. PMID 18799813.