Tropomyosin 3

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Protein TPM3 PDB 1mv4.png
AliasesTPM3, CAPM1, CFTD, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, TRK, hscp30, Tropomyosin 3, TPM3nu
External IDsOMIM: 191030 MGI: 1890149 HomoloGene: 81889 GeneCards: TPM3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TPM3
Genomic location for TPM3
Band1q21.3Start154,155,304 bp[1]
End154,194,648 bp[1]
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 1: 154.16 – 154.19 MbChr 3: 90.07 – 90.1 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.[5][6]

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143549 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027940 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Morris CM, Hao QL, Heisterkamp N, Fitzgerald PH, Groffen J (Aug 1991). "Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24". Oncogene. 6 (6): 1093–5. PMID 1829807.
  6. ^ a b "Entrez Gene: TPM3 tropomyosin 3".

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