Tropomyosin 3

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Tropomyosin 3
Protein TPM3 PDB 1mv4.png
PDB rendering based on 1mv4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TPM3 ; CAPM1; CFTD; HEL-189; HEL-S-82p; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3; TRK; hscp30
External IDs OMIM191030 HomoloGene81889 GeneCards: TPM3 Gene
Species Human Mouse
Entrez 7170 59069
Ensembl ENSG00000143549 ENSMUSG00000027940
UniProt P06753 P21107
RefSeq (mRNA) NM_001043351 NM_001253738
RefSeq (protein) NP_001036816 NP_001240667
Location (UCSC) Chr 1:
154.16 – 154.19 Mb
Chr 3:
90.07 – 90.1 Mb
PubMed search [1] [2]

Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.[1][2]

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Morris CM, Hao QL, Heisterkamp N, Fitzgerald PH, Groffen J (Aug 1991). "Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24". Oncogene 6 (6): 1093–5. PMID 1829807. 
  2. ^ a b "Entrez Gene: TPM3 tropomyosin 3". 

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