Troponin T

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Troponin

Troponin T is a part of the troponin complex, which are proteins integral to the contraction of skeletal and heart muscles. They are expressed in skeletal and cardiac myocytes. Troponin T binds to tropomyosin and helps position it on actin,[1] and together with the rest of the troponin complex, modulates contraction of striated muscle.[2] The cardiac subtype of troponin T is especially useful in the laboratory diagnosis of heart attack because it is released into the blood-stream when damage to heart muscle occurs.[3] It was discovered by the German physician Hugo A. Katus at the University of Heidelberg, who also developed the troponin T assay.

Subtypes[edit]

Reference values[edit]

The 99th percentile cutoff for cardiac troponin T (cTnT) is 0.01 ng/mL.[4] The reference range for the high sensitivity troponin T is a normal < 14 ng/L, borderline of 14-52 ng/L, and elevated of >52 ng/L.[5]

Background[edit]

The troponin complex is responsible for coupling the sarcomere contraction cycle to variations in intracellular calcium concentration. Increased troponin T levels after an episode of chest pain indicates myocardial infarction.[6] It was discovered by the German physician Hugo A. Katus at the University of Heidelberg. He also developed the troponin T assay.[7] In patients with stable coronary artery disease, the troponin T concentration has long been found to be significantly associated with the incidence of cardiovascular death and heart failure, but it was 2014 before it began to be accepted as a predictor of who would later suffer acute myocardial infarction (heart attack).[8][9]

See also[edit]

References[edit]

  1. ^ marieb, elaine (2004)
  2. ^ black, joyce (2005)
  3. ^ Braunwald's Heart Disease. Elsevier Saunders. p. 433. ISBN 978-1-4557-5134-1.
  4. ^ Ashvarya Mangla. "Troponins". medscape. Retrieved 2017-07-24. Updated: Jan 14, 2015
  5. ^ "Troponin T, High Sensitivity". www.calgarylabservices.com. Retrieved 29 August 2019.
  6. ^ Michael A. Chen. "Troponin test". MedlinePlus, U.S. National Library of Medicine. Retrieved 2017-07-24. Review Date 10/6/2015
  7. ^ "Development of the Cardiac Troponin T Immunoassay". American Association for Clinical Chemistry, Inc. 2008. Retrieved 2010-05-01.
  8. ^ "A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease". New England Journal of Medicine. 2009. Retrieved 2012-04-04.
  9. ^ "Health Conditions: Diseases, conditions & medical information - MSN Health & Fitness". healthyliving.msn.com. Retrieved 12 April 2018.

External links[edit]