Troxerutin

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Troxerutin
Troxerutin.svg
Clinical data
SynonymsHydroxyethylrutoside (HER)
Pherarutin
Trihydroxyethylrutin
3',4',7-Tris[O-(2-hydroxyethyl)]rutin
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC33H42O19
Molar mass742.67518 g/mol g·mol−1
3D model (JSmol)
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Troxerutin is a flavonol, a type of flavonoid, derived from rutin.[1] It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the Japanese pagoda tree.

It is used as a vasoprotective.[2]

Troxerutin has been shown in mice to reverse CNS insulin resistance and reduce reactive oxygen species induced by a high-cholesterol diet.[3]

References[edit]

  1. ^ Zhang, ZF; Fan, SH; Zheng, YL; Lu, J; Wu, DM; Shan, Q; Hu, B (2014). "Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice". Biochemical Pharmacology. 91 (1): 74–86. doi:10.1016/j.bcp.2014.07.002. PMID 25026599.
  2. ^ Riccioni, C.; Sarcinella, R.; Izzo, A.; Palermo, G.; Liguori, M. (2004). "Effectiveness of Troxerutin in association with Pycnogenol in the pharmacological treatment of venous insufficiency". Minerva Cardioangiologica. 52 (1): 43–48. PMID 14765037.
  3. ^ Lu, J.; Wu, D. -M.; Zheng, Z. -H.; Zheng, Y. -L.; Hu, B.; Zhang, Z. -F. (2011). "Troxerutin protects against high cholesterol-induced cognitive deficits in mice". Brain. 134 (3): 783–797. doi:10.1093/brain/awq376. PMID 21252113.