Trudy Mackay

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Trudy Mackay

Trudy Frances Charlene Mackay

(1952-09-10) September 10, 1952 (age 66)[1]
Known forDrosophila Genetic Reference Panel
Robert R. H. Anholt (m. 1990)
Scientific career
FieldsQuantitative genetics
InstitutionsNorth Carolina State University
ThesisGenetic variation in varying environments (1979)
Doctoral advisorAlan Robertson[3]

Trudy Frances Charlene Mackay FRS (born 10 September 1952)[1] is the director of Clemson University's Center for Human Genetics[4] located on the campus of the Greenwood (S.C.) Genetic Center.[5] She is recognized as one of the world's leading authorities on the genetics of complex traits. Mackay is also the Self Family Chair in Human Genetics and Professor of Genetics and Biochemistry[6] at Clemson University.[7]

Mackay is a member of the National Academy of Sciences (2010).[8]

Mackay was formerly the William Neal Reynolds and Distinguished University Professor at North Carolina State University,[9][10][11] where she specialized in quantitative genetics.[12][13][14] She is responsible for establishing the Drosophila Genetic Reference Panel.[15]


Mackay received a Bachelor of Science degree in 1974 and Master of Science degree in 1976 in Biology from Dalhousie University.[1] She completed postgraduate study at the University of Edinburgh with a PhD in genetics awarded in 1979 for research supervised by Alan Robertson.[3][16]

Career and research[edit]

Mackay's research investigates the environmental and genetic factors that influence quantitative traits.[17] These phenotypic traits include height or weight and are represented by continuous, rather than discrete, values.[17] Her work is undertaken by studying the impact of natural variants and mutations on many behavioural, morphological, physiological and life history traits in fruit flies, which she uses as a model organism.[17]

The broad importance of such traits gives Mackay's work potential application in many areas — from improving plant breeding and animal breeding to the treatment of human diseases.[17] Mackay is the co-author with Douglas Scott Falconer of the fourth edition of the widely used and highly cited textbook, Introduction to Quantitative Genetics, published in 1996.[18]

Awards and honours[edit]

Mackay was elected a Fellow of the Royal Society (FRS) in 2006.[17] She was awarded the Genetics Society of America Medal in 2004[citation needed] and the Wolf Prize in Agriculture in 2016.[2]

Personal life[edit]

Mackay married Robert R. H. Anholt in 1990.[1]


  1. ^ a b c d e Anon (2017). Mackay, Trudy Frances Charlene, (Mrs R. R. H. Anholt). Who's Who (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.151464. closed access (subscription required)
  2. ^ a b Maguire, Marti (February 6, 2016). "Tar Heel: Trudy Mackay works with fruit flies to solve genetic mysteries". The News & Observer. Retrieved 16 February 2016.
  3. ^ a b Mackay, Trudy Frances Charlene (1979). Genetic variation in varying environments. (PhD thesis). University of Edinburgh. hdl:1842/11082. OCLC 757072704. EThOS Free to read
  4. ^ "Renowned scientist named director of Clemson's Center for Human Genetics". Newsstand | Clemson University News and Stories, South Carolina. Retrieved 2018-08-24.
  5. ^ "The Greenwood Genetic Center". Retrieved 2018-08-24.
  6. ^ "Salute to Faculty Excellence | College of Science, Clemson University, South Carolina". Retrieved 2018-08-24.
  7. ^ "Clemson University, South Carolina". Retrieved 2018-08-24.
  8. ^, National Academy of Sciences -. "Trudy Mackay". Retrieved 2018-08-24.
  9. ^ "Mackay Homepage". Archived from the original on 2008-04-23. Retrieved 2008-07-21. Faculty webpage
  10. ^ Mackay, Trudy (2006). "Trudy Mackay". Current Biology. 16 (17): R659–R661. doi:10.1016/j.cub.2006.08.016. ISSN 0960-9822. Free to read
  11. ^ "NC State: Trudy Mackay". YouTube.
  12. ^ Mackay, Trudy F. C.; Stone, Eric A.; Ayroles, Julien F. (2009). "The genetics of quantitative traits: challenges and prospects". Nature Reviews Genetics. 10 (8): 565–577. doi:10.1038/nrg2612. ISSN 1471-0056. PMID 19584810. closed access
  13. ^ Mackay, Trudy F. C. (2001). "The Genetic Architecture of Quantitative Traits". Annual Review of Genetics. 35 (1): 303–339. doi:10.1146/annurev.genet.35.102401.090633. ISSN 0066-4197. PMID 11700286. closed access
  14. ^ Manolio, Teri A.; Collins, Francis S.; Cox, Nancy J.; Goldstein, David B.; Hindorff, Lucia A.; Hunter, David J.; McCarthy, Mark I.; Ramos, Erin M.; Cardon, Lon R.; Chakravarti, Aravinda; Cho, Judy H.; Guttmacher, Alan E.; Kong, Augustine; Kruglyak, Leonid; Mardis, Elaine; Rotimi, Charles N.; Slatkin, Montgomery; Valle, David; Whittemore, Alice S.; Boehnke, Michael; Clark, Andrew G.; Eichler, Evan E.; Gibson, Greg; Haines, Jonathan L.; Mackay, Trudy F. C.; McCarroll, Steven A.; Visscher, Peter M. (2009). "Finding the missing heritability of complex diseases". Nature. 461 (7265): 747–753. doi:10.1038/nature08494. ISSN 0028-0836. PMC 2831613. PMID 19812666.
  15. ^ Mackay, Trudy F. C.; Richards, Stephen; Stone, Eric A.; Barbadilla, Antonio; Ayroles, Julien F.; Zhu, Dianhui; Casillas, Sònia; Han, Yi; Magwire, Michael M.; Cridland, Julie M.; Richardson, Mark F.; et al. (2012). "The Drosophila melanogaster Genetic Reference Panel". Nature. 482 (7384): 173–178. doi:10.1038/nature10811. ISSN 0028-0836. PMC 3683990. PMID 22318601.
  16. ^ "Trudy Mackay CV" (PDF).
  17. ^ a b c d e Anon (2006). "Professor Trudy Mackay FRS". London: Royal Society. Archived from the original on 2015-11-17. One or more of the preceding sentences incorporates text from the website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on 2016-11-11. Retrieved 2016-03-09.CS1 maint: BOT: original-url status unknown (link)

  18. ^ Falconer, Douglas; Mackay, Trudy F. C. (1996). Introduction to quantitative genetics (4th ed.). Essex, England: Longman. ISBN 9780582243026. OCLC 34415160.