At first he studied architecture and later this influence has shown up in his manga works in his depiction of huge structures. This has become one of the general themes that make his manga unique. His works are usually in black and white.
Blame! - Nihei's first work, detailing the adventures of Killy as he searches for a human with compatible genes to save the world. Originally published in Afternoon, it also gained a 6 episode ONA.
NOiSE - A prequel to Blame!, in which a police officer investigates the murder of a gang. Originally publishing in Afternoon.
Abara - Published in Ultra Jump, Abara follows Denji Kudou, a man able to transform into a Gauna – a creature with bone-like armor and weaponry.
Biomega - Zouichi Kanoe and the AI in his motorbike set out to find humans resistant to N5S, a virus that turns people into zombie-like "Drones". Originally appeared in Young Magazine.
Knights of Sidonia - Nihei's latest series set in the far future about a human colony ship's war against an elusive alien race known as the "Gauna". It is currently running in Afternoon and is the first of Nihei's works to be adapted into a TV series. In 2015, Knights of Sidonia won the "General" category of the prestigious Kodansha Manga Awards.
Bitch's Life - An erotic illustrations book, featuring contributions from over twenty manga artists; four of which come from Nihei.
Blame! and So On - Published in 2003, Blame! and So On contains artwork and sketches for Blame!, Noise, and Wolverine: Snikt!, amongst others; it also contains the illustrations Nihei provided for Bitch's Life and the aborted Dead Heads as thumbnails.