Tuftelin

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TUFT1
Identifiers
Aliases TUFT1, entrez:7286
External IDs OMIM: 600087 MGI: 109572 HomoloGene: 7985 GeneCards: TUFT1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001126337
NM_001301317
NM_020127

NM_011656
NM_001293728

RefSeq (protein)

NP_001119809
NP_001288246
NP_064512

NP_035786.1
NP_001280657
NP_035786

Location (UCSC) Chr 1: 151.54 – 151.58 Mb Chr 3: 94.61 – 94.66 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tuftelin is an acidic phosphorylated glycoprotein found in tooth enamel. In humans, the Tuftelin protein is encoded by the TUFT1 gene.[3][4]

Function[edit]

This protein is formed for a short time during amelogenesis. The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel during tooth development.[5][6]

Other significant proteins in enamel are amelogenins, enamelins, and ameloblastins.

Research[edit]

The human encoding gene for tuftelin (TUFT1) was cloned by Profs. Dany Deutsch and Aharon Palmon from the Hebrew University-Hadassah School of Dental Medicine in Jerusalem.[4]

Interactions[edit]

Tuftelin has been shown to interact with TFIP11.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: TUFT1 tuftelin 1". 
  4. ^ a b Deutsch D, Palmon A, Young MF, Selig S, Kearns WG, Fisher LW (July 1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization". Mamm. Genome. 5 (7): 461–2. doi:10.1007/BF00357011. PMID 7919663. 
  5. ^ Deutsch D (June 1989). "Structure and function of enamel gene products". Anat. Rec. 224 (2): 189–210. doi:10.1002/ar.1092240209. PMID 2672884. 
  6. ^ Deutsch D, Palmon A, Fisher LW, Kolodny N, Termine JD, Young MF (August 1991). "Sequencing of bovine enamelin ("tuftelin") a novel acidic enamel protein". J. Biol. Chem. 266 (24): 16021–8. PMID 1874744. 
  7. ^ Paine, C T; Paine M L; Luo W; Okamoto C T; Lyngstadaas S P; Snead M L (July 2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. UNITED STATES. 275 (29): 22284–92. doi:10.1074/jbc.M000118200. ISSN 0021-9258. PMID 10806191. 

Further reading[edit]