Tuftelin

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TUFT1
Identifiers
AliasesTUFT1, entrez:7286, tuftelin 1
External IDsOMIM: 600087 MGI: 109572 HomoloGene: 7985 GeneCards: TUFT1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TUFT1
Genomic location for TUFT1
Band1q21.3Start151,540,305 bp[1]
End151,583,583 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001126337
NM_001301317
NM_020127

NM_011656
NM_001293728

RefSeq (protein)

NP_001119809
NP_001288246
NP_064512

NP_001280657
NP_035786

Location (UCSC)Chr 1: 151.54 – 151.58 MbChr 3: 94.61 – 94.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tuftelin is an acidic phosphorylated glycoprotein found in tooth enamel. In humans, the Tuftelin protein is encoded by the TUFT1 gene.[5][6] It is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation.[7]

Classification[edit]

There are two kinds of enamel proteins: Amelogenins & Nonamelogenins. Tuftelin falls under nonamelogenins.[8]

Function[edit]

This protein is formed for a short time during amelogenesis. The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel during tooth development.[9][10]

Other significant proteins in enamel are amelogenins, enamelins, and ameloblastins.

Research[edit]

The human encoding gene for tuftelin (TUFT1) was cloned by Profs. Dany Deutsch and Aharon Palmon from the Hebrew University-Hadassah School of Dental Medicine in Jerusalem.[6]

Interactions[edit]

Tuftelin has been shown to interact with TFIP11.[11]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143367 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005968 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: TUFT1 tuftelin 1".
  6. ^ a b Deutsch D, Palmon A, Young MF, Selig S, Kearns WG, Fisher LW (July 1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization". Mamm. Genome. 5 (7): 461–2. doi:10.1007/BF00357011. PMID 7919663.
  7. ^ "TUFT1 tuftelin 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-03-05.
  8. ^ Nanci, Antonio (2017-08-15). Ten Cate's Oral Histology - E-Book: Development, Structure, and Function. Elsevier Health Sciences. ISBN 9780323485180.
  9. ^ Deutsch D (June 1989). "Structure and function of enamel gene products". Anat. Rec. 224 (2): 189–210. doi:10.1002/ar.1092240209. PMID 2672884.
  10. ^ Deutsch D, Palmon A, Fisher LW, Kolodny N, Termine JD, Young MF (August 1991). "Sequencing of bovine enamelin ("tuftelin") a novel acidic enamel protein". J. Biol. Chem. 266 (24): 16021–8. PMID 1874744.
  11. ^ Paine, C T; Paine M L; Luo W; Okamoto C T; Lyngstadaas S P; Snead M L (July 2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. UNITED STATES. 275 (29): 22284–92. doi:10.1074/jbc.M000118200. ISSN 0021-9258. PMID 10806191.

Further reading[edit]