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Virus classification
Group V ((−)ssRNA)
Type species
Durham tupavirus
  • Durham tupavirus
  • Tupaia tupavirus

Tupavirus is a genus of viruses in the family Rhabdoviridae, order Mononegavirales.[1][2]


Genus Tupavirus: species and their viruses[3]
Genus Species Virus (Abbreviation)
Tupavirus Durham tupavirus* Durham virus (DURV)
Tupaia tupavirus tupaia virus (TUPV)

Table legend: "*" denotes type species.


Tupavirions enveloped, with bullet shaped geometries. These particles are about 160 nm long. Tupavirus genomes are linear, around 11.2 kb in length. The genome codes for 7 proteins.[1]

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation
Tupavirus Bullet-shaped Enveloped Linear

Life cycle[edit]

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral G glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering is the method of transcription. The virus exits the host cell by budding, and tubule-guided viral movement. Birds serve as the natural host for Durham tupavirus[1], with antibodies having been found in the American Coot (Fulica americana)[4]. Additionally, antibodies for Klamath tupavirus have been found in several species of deer, bison, and humans.[4], as well as voles and shrews[4].

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Tupavirus Birds None Clathrin-mediated endocytosis Budding Cytoplasm Cytoplasm Unknown


  1. ^ a b c "Viral Zone". ExPASy. Retrieved 13 August 2015.
  2. ^ ICTV. "Virus Taxonomy: 2014 Release". Retrieved 13 August 2015.
  3. ^ Afonso, Claudio L.; Amarasinghe, Gaya K.; Bányai, Krisztián; Bào, Yīmíng; Basler, Christopher F.; Bavari, Sina; Bejerman, Nicolás; Blasdell, Kim R.; Briand, François-Xavier (1 August 2016). "Taxonomy of the order Mononegavirales: update 2016". Archives of Virology. 161 (8): 2351–2360. doi:10.1007/s00705-016-2880-1. ISSN 1432-8798. PMC 4947412. PMID 27216929.
  4. ^ a b c ICTV. "Genus: Tupavirus". Retrieved 12 August 2019.

External links[edit]