Tussilago farfara, commonly known as coltsfoot,:770 is a plant in the groundsel tribe in the daisy family Asteraceae, native to Europe and parts of western and central Asia. It has had uses in traditional medicine. The name "tussilago" is derived from the Latin tussis, meaning cough, and ago, meaning to cast or to act on. However, the discovery of toxic pyrrolizidine alkaloids in the plant has resulted in liver health concerns.
Tussilago farfara is the only accepted species in the genus Tussilago, although more than two dozen other species have at one time or another been considered part of this group. Most of them are now regarded as members of other genera (Chaptalia, Chevreulia, Farfugium, Homogyne, Leibnitzia, Petasites, Senecio).
Coltsfoot is a perennial herbaceous plant that spreads by seeds and rhizomes. Tussilago is often found in colonies of dozens of plants. The flowers, which superficially resemble dandelions, appear in early spring before dandelions appear. The leaves, which resemble a colt's foot in cross section, do not appear usually until after the seeds are set. Thus, the flowers appear on stems with no apparent leaves, and the later appearing leaves then wither and die during the season without seeming to set flowers. The plant is typically 10–30 cm in height. The leaves have angular teeth on their margins.
Coltsfoot is widespread across Europe, Asia, and North Africa, from Svalbard to Morocco to China and the Russian Far East. It is also a common plant in North America and South America where it has been introduced, most likely by settlers as a medicinal item. The plant is often found in waste and disturbed places and along roadsides and paths. In some areas it is considered an invasive species.
Other common names include tash plant, ass's foot, bull's foot, coughwort (Old English), farfara, foal's foot, foalswort and horse foot. Sometimes it is confused with Petasites frigidus, or western coltsfoot.
Coltsfoot has been used in herbal medicine and has been consumed as a food product with some confectionery products, such as Coltsfoot Rock. Tussilago farfara leaves have been used in the traditional Austrian medicine internally (as tea or syrup) or externally (directly applied) for treatment of disorders of the respiratory tract, skin, locomotor system, viral infections, flu, colds, fever, rheumatism and gout.
Tussilago farfara contains tumorigenic pyrrolizidine alkaloids. Senecionine and senkirkine, present in coltsfoot, have the highest mutagenetic activity of any pyrrolozidine alkaloid, tested using Drosophila melanogaster to produce a comparative genotoxicity test. There are documented cases of coltsfoot tea causing severe liver problems in an infant, and in another case, an infant developed liver disease and died because the mother drank tea containing coltsfoot during her pregnancy. In response the German government banned the sale of coltsfoot. Clonal plants of colstfoot free of pyrrolizidine alkaloids were then developed in Austria and Germany. This has resulted in the development of the registered variety Tussilago farfara 'Wien' which has no detectable levels of these alkaloids.
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